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Bis-tris methane

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Bis-tris methane
Skeletal formula of bis-tris methane
Names
Preferred IUPAC name 2--2-(hydroxymethyl)propane-1,3-diol
Other names
  • Bis-(2-hydroxy-ethyl)-amino-tris(hydroxymethyl)-methane
  • 2--2-(hydroxymethyl)-1,3-propanediol
  • 2,2-Bis(hydroxymethyl)-2,2,2-nitrilotriethanol
Identifiers
CAS Number
3D model (JSmol)
Beilstein Reference 2205275
ChEBI
ChemSpider
ECHA InfoCard 100.027.489 Edit this at Wikidata
EC Number
  • 230-237-7
Gmelin Reference 4519
MeSH Bistris
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C8H19NO5/c10-3-1-9(2-4-11)8(5-12,6-13)7-14/h10-14H,1-7H2Key: OWMVSZAMULFTJU-UHFFFAOYSA-N
SMILES
  • OCCN(CCO)C(CO)(CO)CO
Properties
Chemical formula C8H19NO5
Molar mass 209.242 g·mol
Appearance White crystals
Odor Odourless
Melting point 102 to 103 °C (216 to 217 °F; 375 to 376 K)
Solubility in water 209.2 g L (at 20 °C)
Acidity (pKa) 6.46
Basicity (pKb) 7.54
UV-vis (λmax) 280 nm
Absorbance 0.15
Hazards
GHS labelling:
Pictograms GHS07: Exclamation mark
Signal word Warning
Hazard statements H315, H319, H335
Precautionary statements P261, P305+P351+P338
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g. chloroformFlammability 0: Will not burn. E.g. waterInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
2 0 0
Related compounds
Related alkanols
Related compounds Diethylhydroxylamine
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Bis-tris methane, also known as BIS-TRIS or BTM, is a buffering agent used in biochemistry. Bis-tris methane is an organic tertiary amine with labile protons having a pKa of 6.46 at 25 °C. It is an effective buffer between the pH 5.8 and 7.2. Bis-tris methane binds strongly to Cu and Pb ions as well as, weakly, to Mg, Ca, Mn, Co, Ni, Zn and Cd.

See also

References

  1. "Bistris - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 23 June 2005. Identification. Retrieved 9 April 2012.
  2. Ferreira, Carlos M. H.; Pinto, Isabel S. S.; Soares, Eduardo V.; Soares, Helena M. V. M. (2015). "(Un)suitability of the use of pH buffers in biological, biochemical and environmental studies and their interaction with metal ions – a review". RSC Advances. 5 (39): 30989–31003. doi:10.1039/c4ra15453c. hdl:10400.22/7404. ISSN 2046-2069.
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