Blackley is a toponymic surname that refers to the suburban area of Manchester. Notable people with the surname include:
- Adam Blackley (born 1985), Australian baseball player
- Charles Harrison Blackley (1820–1900), English physician
- Jamie Blackley (born 1991), British actor
- Jim Blackley (born 1927), Scottish-born Canadian jazz drummer
- John Blackley (born 1948), Scottish footballer and manager
- John Blackley (politician) (1862–1952), Australian politician
- Len Blackley (1915–1983), Australian rules footballer
- Seamus Blackley, American video game designer
- Travis Blackley (born 1982), Australian baseball player
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