| BolA | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 solution structure of protein yrba from escherichia coli: northeast structural genomics consortium target er115 | |||||||||
| Identifiers | |||||||||
| Symbol | BolA | ||||||||
| Pfam | PF01722 | ||||||||
| InterPro | IPR002634 | ||||||||
| SCOP2 | 1v9j / SCOPe / SUPFAM | ||||||||
| |||||||||
In molecular biology, the BolA-like protein family consists of the morpho-protein BolA from Escherichia coli, the Fra2 protein from Saccharomyces cerevisiae, and various homologs. The BolA protein is a DNA-binding regulator; the Fra2 protein is an iron sulfur cluster protein that binds Grx3/4 and is involved in regulating iron levels .
In E. coli, over-expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.
References
- Dressaire C, Moreira RN, Barahona S, Alves de Matos AP, Arraiano CM, Santos JM, Freire P, Vicente M, Arraiano CM (17 February 2015). "BolA Is a Transcriptional Switch That Turns Off Motility and Turns On Biofilm Development". mBio. 6 (1): e02352-14. doi:10.1128/mBio.02352-14. PMC 4337573. PMID 25691594.
- Li H, Mapolelo DT, Dingra NN, Naik SG, Lees NS, Hoffman BM, Riggs-Gelasco PJ, Huynh BH, Johnson MK, Outten CE (2009). "The yeast iron regulatory proteins Grx3/4 and Fra2 form heterodimeric complexes containing a [2Fe-2S] cluster with cysteinyl and histidyl ligation". Biochemistry. 48 (40): 9569–81. doi:10.1021/bi901182w. PMC 2796373. PMID 19715344.
- ^ Santos JM, Freire P, Vicente M, Arraiano CM (May 1999). "The stationary-phase morphogene bolA from Escherichia coli is induced by stress during early stages of growth". Mol. Microbiol. 32 (4): 789–98. doi:10.1046/j.1365-2958.1999.01397.x. PMID 10361282. S2CID 25213524.
- Aldea M, Garrido T, Hernandez-Chico C, Vicente M, Kushner SR (December 1989). "Induction of a growth-phase-dependent promoter triggers transcription of bolA, an Escherichia coli morphogene". EMBO J. 8 (12): 3923–31. doi:10.1002/j.1460-2075.1989.tb08573.x. PMC 402084. PMID 2684651.