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BMP8B
Identifiers
Aliases	BMP8B, BMP8, OP2, bone morphogenetic protein 8b
External IDs	OMIM: 602284; MGI: 104515; HomoloGene: 74865; GeneCards: BMP8B; OMA:BMP8B - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.2 Start 39,757,182 bp End 39,788,865 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D2.2|4 57.42 cM Start 123,206,438 bp End 123,237,045 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia spinal ganglia trigeminal ganglion jejunal mucosa tibial nerve retinal pigment epithelium sural nerve trabecular bone duodenum mucosa of colon Top expressed in decidua gastrula intestinal villus calvaria hair follicle molar jejunum embryo Ileal epithelium body of femur More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transforming growth factor beta receptor binding cytokine activity BMP receptor binding growth factor activity Cellular component extracellular region extracellular space Biological process regulation of apoptotic process multicellular organism development skeletal system development positive regulation of pathway-restricted SMAD protein phosphorylation cartilage development cell differentiation regulation of MAPK cascade SMAD protein signal transduction cell development BMP signaling pathway ossification regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 656 12163 Ensembl ENSG00000116985 ENSMUSG00000032726 UniProt P34820 P34821 RefSeq (mRNA) NM_001720 NM_001256019 NM_007558 RefSeq (protein) NP_001711 NP_001242948 NP_031584 Location (UCSC) Chr 1: 39.76 – 39.79 Mb Chr 4: 123.21 – 123.24 Mb PubMed search
Wikidata
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Bone morphogenetic protein 8B is a protein that in humans is encoded by the BMP8B gene.

The protein encoded by this gene is a member of the TGF-β superfamily. It has close sequence homology to BMP7 and BMP5 and is believed to play a role in bone and cartilage development. It has been shown to be expressed in the hippocampus of murine embryos.

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000116985 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000032726 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ozkaynak E, Schnegelsberg PN, Jin DF, Clifford GM, Warren FD, Drier EA, Oppermann H (Jan 1993). "Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis". J Biol Chem. 267 (35): 25220–7. doi:10.1016/S0021-9258(19)74028-9. PMID 1460021.
6. DiLeone RJ, King JA, Storm EE, Copeland NG, Jenkins NA, Kingsley DM (Jun 1997). "The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4". Genomics. 40 (1): 196–8. doi:10.1006/geno.1996.4533. PMID 9070944.
7. ^ "Entrez Gene: BMP8B bone morphogenetic protein 8b (osteogenic protein 2)".

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Wen XZ, Akiyama Y, Baylin SB, Yuasa Y (2006). "Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas". Oncogene. 25 (18): 2666–73. doi:10.1038/sj.onc.1209297. PMID 16314833.
• Saito T, Ji G, Shinzawa H, et al. (2004). "Genetic variations in humans associated with differences in the course of hepatitis C". Biochem. Biophys. Res. Commun. 317 (2): 335–41. doi:10.1016/j.bbrc.2004.03.056. PMID 15063762.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ying Y, Qi X, Zhao GQ (2001). "Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways". Proc. Natl. Acad. Sci. U.S.A. 98 (14): 7858–62. Bibcode:2001PNAS...98.7858Y. doi:10.1073/pnas.151242798. PMC 35432. PMID 11427739.
• Ying Y, Liu XM, Marble A, et al. (2000). "Requirement of Bmp8b for the generation of primordial germ cells in the mouse". Mol. Endocrinol. 14 (7): 1053–63. doi:10.1210/mend.14.7.0479. PMID 10894154.
• Auffray C, Behar G, Bois F, et al. (1995). "". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.

External links

• Human BMP8B genome location and BMP8B gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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