Bonsignore is a surname. Notable people with the surname include:
- Ferdinando Bonsignore (1760–1843), Italian architect and designer
- Gregory Bonsignore (born 1983), American playwright and screenwriter
- Jason Bonsignore (born 1976) American hockey player
- Justin Bonsignore (born 1988), American racing driver
- Michael Bonsignore, American business executive
- Vito Bonsignore (born 1943), Italian politician
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