Brandegee is a surname. Notable people with the surname include:
- Augustus Brandegee (1828–1904), American lawyer and politician
- Frank B. Brandegee (1864–1924), American politician
- Mary Katharine Brandegee (1844–1920), American botanist
- Townshend Stith Brandegee (1843–1925), American botanist
See also
- Brandegee Estate, a historic estate in Massachusetts
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