Brendel is a surname. Notable people with the surname include:
- Albert Brendel, various people
- Alfred Brendel (born 1931), pianist
- Brian Brendell (born 1986), Namibian footballer
- El Brendel (1890–1964), American entertainer
- Daniela Brendel (born 1973), German swimmer
- Franz Brendel (1811–1868), 19th-century music critic and publisher
- Franz Brendel (canoeist), German canoeist
- Günther Brendel (born 1930), German painter
- Henry W. Brendel (1857–1940), American lawyer and government official
- Jake Brendel (born 1992), American football player
- Jakob Brendel (1907–1964), German wrestler
- Joachim Brendel (1921–1974), German Luftwaffe pilot
- Karl Brendel (1871–1925), German sculptor
- Leif Brendel (1903–1972), Norwegian editor
- Maria Weigert Brendel (1902–1994), German classical art expert, wife of Otto Brendel
- Martin Brendel (1862–1939), German astronomer
- Neal Brendel (1954–2021), American rugby union player and lawyer
- Otto Brendel (1901–1973), scholar of Etruscan art
- Pascal Brendel (born 2003), German gymnast
- Robert Brendel (c. 1821–1898), German botanist and model maker
- Sarah Brendel (born 1976), German pop singer
- Sebastian Brendel (born 1988), German canoeist
- Willi Brendel (1938–2006), German field hockey player
- Wolfgang Brendel (born 1947), German opera singer
See also
- Brendel Anstey (1887–1933), English footballer
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