Brindle is a surname. Notable people with the name include:
- Arran Brindle (born 1981), English cricketer, member of the England Women's team
- Dave Brindle, Canadian broadcast journalist and producer
- Frederick Brindle (born 1909), English professional rugby league footballer
- Melbourne Brindle (1904–1995), Australian-American illustrator and painter
- Reginald Brindle (1925–1998), English cricketer
- Reginald Smith Brindle (1917–2003), British composer and writer
- Robert Brindle (1837–1916), English prelate of the Roman Catholic Church
- Timothy Brindle (born 1980), American Christian hip hop musician
- Tom Brindle (disambiguation), multiple people, including:
- Tom Brindle (footballer) (1861–1905), English footballer
- Tom Brindle (politician) (1878–1950), member of the New Zealand Legislative Council
- Brindle, Brindle Family from Small Wonder
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