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ECRG4
Identifiers
Aliases	ECRG4, chromosome 2 open reading frame 40, C2orf40, UNQ761/PRO1508, ECRG4 augurin precursor
External IDs	OMIM: 611752; MGI: 1926146; HomoloGene: 11505; GeneCards: ECRG4; OMA:ECRG4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q12.2 Start 106,063,246 bp End 106,078,155 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C1.1 Start 43,769,762 bp End 43,781,738 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa bronchial epithelial cell synovial membrane cartilage tissue right coronary artery tibia synovial joint trachea left coronary artery spinal ganglia Top expressed in Epithelium of choroid plexus adrenal gland calvaria vestibular sensory epithelium epithelium of lens intercostal muscle tibiofemoral joint ankle condyle aortic valve More reference expression data BioGPS n/a
Gene ontology Molecular function neuropeptide hormone activity Cellular component extracellular region transport vesicle cytoplasmic vesicle extracellular space dense core granule cytoplasm apical plasma membrane plasma membrane membrane Biological process cellular senescence G1 to G0 transition anaphase-promoting complex-dependent catabolic process neuropeptide signaling pathway central nervous system development negative regulation of cell population proliferation response to wounding vasopressin secretion positive regulation of corticotropin secretion positive regulation of corticotropin-releasing hormone secretion positive regulation of corticosterone secretion regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84417 78896 Ensembl ENSG00000119147 ENSMUSG00000026051 UniProt Q9H1Z8 Q99LS0 RefSeq (mRNA) NM_032411 NM_024283 RefSeq (protein) NP_115787 NP_115787 NP_077245 Location (UCSC) Chr 2: 106.06 – 106.08 Mb Chr 1: 43.77 – 43.78 Mb PubMed search
Wikidata
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Augurin is a protein that in humans is encoded by the C2orf40 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000119147 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000026051 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Chromosome 2 open reading frame 40". Retrieved 2018-09-05.

Further reading

• Yue CM, Deng DJ, Bi MX, Guo LP, Lu SH (June 2003). "Expression of ECRG4, a novel esophageal cancer-related gene, downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma". World J. Gastroenterol. 9 (6): 1174–8. doi:10.3748/wjg.v9.i6.1174. PMC 4611778. PMID 12800218.
• Mori Y, Ishiguro H, Kuwabara Y, Kimura M, Mitsui A, Kurehara H, Mori R, Tomoda K, Ogawa R, Katada T, Harata K, Fujii Y (October 2007). "Expression of ECRG4 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma". Oncol. Rep. 18 (4): 981–5. PMID 17786363.
• Li LW, Yu XY, Yang Y, Zhang CP, Guo LP, Lu SH (October 2009). "Expression of esophageal cancer related gene 4 (ECRG4), a novel tumor suppressor gene, in esophageal cancer and its inhibitory effect on the tumor growth in vitro and in vivo". Int. J. Cancer. 125 (7): 1505–13. doi:10.1002/ijc.24513. PMID 19521989. S2CID 12122816.
• Götze S, Feldhaus V, Traska T, Wolter M, Reifenberger G, Tannapfel A, Kuhnen C, Martin D, Müller O, Sievers S (December 2009). "ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma". BMC Cancer. 9: 447. doi:10.1186/1471-2407-9-447. PMC 2804712. PMID 20017917.
• Li W, Liu X, Zhang B, Qi D, Zhang L, Jin Y, Yang H (July 2010). "Overexpression of candidate tumor suppressor ECRG4 inhibits glioma proliferation and invasion". J. Exp. Clin. Cancer Res. 29 (1): 89. doi:10.1186/1756-9966-29-89. PMC 2913949. PMID 20598162.
• Li LW, Li YY, Li XY, Zhang CP, Zhou Y, Lu SH (February 2011). "A novel tumor suppressor gene ECRG4 interacts directly with TMPRSS11A (ECRG1) to inhibit cancer cell growth in esophageal carcinoma". BMC Cancer. 11: 52. doi:10.1186/1471-2407-11-52. PMC 3039630. PMID 21288367.
• Podvin S, Gonzalez AM, Miller MC, Dang X, Botfield H, Donahue JE, Kurabi A, Boissaud-Cooke M, Rossi R, Leadbeater WE, Johanson CE, Coimbra R, Stopa EG, Eliceiri BP, Baird A (2011). "Esophageal cancer related gene-4 is a choroid plexus-derived injury response gene: evidence for a biphasic response in early and late brain injury". PLOS ONE. 6 (9): e24609. Bibcode:2011PLoSO...624609P. doi:10.1371/journal.pone.0024609. PMC 3173480. PMID 21935431.
• Sabatier R, Finetti P, Adelaide J, Guille A, Borg JP, Chaffanet M, Lane L, Birnbaum D, Bertucci F (2011). "Down-regulation of ECRG4, a candidate tumor suppressor gene, in human breast cancer". PLOS ONE. 6 (11): e27656. Bibcode:2011PLoSO...627656S. doi:10.1371/journal.pone.0027656. PMC 3218004. PMID 22110708.
• Li LW, Yu XY, Li XY, Guo LP, Zhou Y, Lu SX (August 2011). "". Zhonghua Zhong Liu Za Zhi (in Chinese). 33 (8): 570–3. PMID 22325214.

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