Protein-coding gene in humans
Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene .
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein Interactions
CACYBP has been shown to interact with SKP1A and SIAH1 .
The CacyBP/SIP complex instead, is known to be a part of stress respons, since it interacts with chaperone HSP90 .
References
^ GRCh38: Ensembl release 89: ENSG00000116161 – Ensembl , May 2017
^ GRCm38: Ensembl release 89: ENSMUSG00000014226 – Ensembl , May 2017
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine ."Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Matsuzawa SI, Reed JC (May 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses" . Molecular Cell . 7 (5): 915–26. doi :10.1016/S1097-2765(01)00242-8 . PMID 11389839 .
Matsuzawa S, Li C, Ni CZ, Takayama S, Reed JC, Ely KR (January 2003). "Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP)" . The Journal of Biological Chemistry . 278 (3): 1837–40. doi :10.1074/jbc.M210263200 . PMID 12421809 .
^ "Entrez Gene: CACYBP calcyclin binding protein" .
Matsuzawa SI, Reed JC (May 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses" . Molecular Cell . 7 (5): 915–26. doi :10.1016/S1097-2765(01)00242-8 . PMID 11389839 .
Filipek, Anna; Leśniak, Wiesława (2018-12-29). "Aktualny pogląd na komórkową funkcję S100A6 i jego ligandów, CacyBP/SIP i Sgt1" . Postępy Biochemii (in Polish). 64 (3): 242–252. doi :10.18388/pb.2018_136 . ISSN 0032-5422 . PMID 30656909 .
External links
Further reading
Filipek A, Jastrzebska B, Nowotny M, Kwiatkowska K, Hetman M, Surmacz L, et al. (June 2002). "Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells" . The Journal of Biological Chemistry . 277 (23): 21103–9. doi :10.1074/jbc.M111010200 . PMID 11927578 . Liu WX, Wu J, Zhao Z, Zhou Y, Peng XZ, Yuan JG, Qiang BQ (March 2002). "". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica . 34 (2): 181–6. PMID 12006993 . Filipek A, Jastrzebska B, Nowotny M, Kuznicki J (August 2002). "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family" . The Journal of Biological Chemistry . 277 (32): 28848–52. doi :10.1074/jbc.M203602200 . PMID 12042313 . Wu J, Tan X, Peng X, Yuan J, Qiang B (July 2003). "Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells" . Journal of Biochemistry and Molecular Biology . 36 (4): 354–8. doi :10.5483/bmbrep.2003.36.4.354 . PMID 12895292 . Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, et al. (October 2005). "Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex" . The Journal of Biological Chemistry . 280 (40): 34278–87. doi :10.1074/jbc.M506707200 . PMID 16085652 . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Molecular Systems Biology . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 . PMID 17353931 . Sun S, Ning X, Liu J, Liu L, Chen Y, Han S, et al. (May 2007). "Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma". Biochemical and Biophysical Research Communications . 356 (4): 864–71. doi :10.1016/j.bbrc.2007.03.080 . PMID 17400182 . PDB gallery
1x5m : Solution structure of the core domain of calcyclin binding protein; siah-interacting protein (SIP)
2a26 : Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein
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