Misplaced Pages

CCNC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RGF, 4F6S, 4F6U, 4F6W, 4F70, 4F7J, 4F7L, 4F7N, 4F7S, 4G6L, 4CRL, 5HBE, 5HBH, 5BNJ, 5HBJ, 5FGK, 5CEI, 5HNB, 5HVY, 5I5Z
Identifiers
Aliases	CCNC, CycC, cyclin C, hSRB11, SRB11
External IDs	OMIM: 123838; MGI: 1858199; HomoloGene: 3803; GeneCards: CCNC; OMA:CCNC - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q16.2 Start 99,542,387 bp End 99,568,825 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A3 Start 21,727,701 bp End 21,759,922 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland oral cavity corpus epididymis jejunal mucosa islet of Langerhans nasal epithelium mucosa of sigmoid colon skin of thigh caput epididymis amniotic fluid Top expressed in spermatid spermatocyte ventricular zone right kidney embryo pineal gland ventral tegmental area medial vestibular nucleus genital tubercle dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase regulator activity Cellular component mediator complex cyclin-dependent protein kinase holoenzyme complex nucleus nucleoplasm Biological process positive regulation of phosphorylation of RNA polymerase II C-terminal domain transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription by RNA polymerase II protein phosphorylation transcription, DNA-templated regulation of cyclin-dependent protein serine/threonine kinase activity regulation of transcription by RNA polymerase II regulation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 892 51813 Ensembl ENSG00000112237 ENSMUSG00000028252 UniProt P24863 Q62447 RefSeq (mRNA) NM_001013399 NM_005190 NM_001363537 NM_001122982 NM_001290420 NM_001290422 NM_016746 RefSeq (protein) NP_001013417 NP_005181 NP_001350466 NP_001116454 NP_001277349 NP_001277351 NP_058026 Location (UCSC) Chr 6: 99.54 – 99.57 Mb Chr 4: 21.73 – 21.76 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Cyclin-C is a protein that in humans is encoded by the CCNC gene.

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

CCNC (gene) has been shown to interact with Estrogen receptor alpha and Cyclin-dependent kinase 8.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000112237 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028252 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lew DJ, Dulic V, Reed SI (Oct 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell. 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066. S2CID 12166415.
6. ^ "Entrez Gene: CCNC cyclin C".
7. ^ Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. Bibcode:2002PNAS...99.2642K. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769.
8. Zhang, Y; Iratni R; Erdjument-Bromage H; Tempst P; Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. 89 (3): 357–64. doi:10.1016/S0092-8674(00)80216-0. ISSN 0092-8674. PMID 9150135.
9. Cho, H; Orphanides G; Sun X; Yang X J; Ogryzko V; Lees E; Nakatani Y; Reinberg D (Sep 1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. 18 (9): 5355–63. doi:10.1128/MCB.18.9.5355. ISSN 0270-7306. PMC 109120. PMID 9710619.
10. Wang, G; Cantin G T; Stevens J L; Berk A J (Jul 2001). "Characterization of Mediator Complexes from HeLa Cell Nuclear Extract". Mol. Cell. Biol. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. ISSN 0270-7306. PMC 87123. PMID 11416138.
11. Tassan, J P; Jaquenoud M; Léopold P; Schultz S J; Nigg E A (Sep 1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8871–5. Bibcode:1995PNAS...92.8871T. doi:10.1073/pnas.92.19.8871. ISSN 0027-8424. PMC 41069. PMID 7568034.

External links

• Human CCNC genome location and CCNC gene details page in the UCSC Genome Browser.

Further reading

• Nozawa T, Hatano M, Yamamoto H, Kwan T (1976). "Magnetic circular dichroism on the reversible oxygenation of dimethylmesoporphyrin-IX-atopyridinecobalt (II)". Bioinorganic Chemistry. 5 (3): 267–73. doi:10.1016/S0006-3061(00)82025-6. PMID 1260071.
• Tassan JP, Jaquenoud M, Léopold P, et al. (1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8871–5. Bibcode:1995PNAS...92.8871T. doi:10.1073/pnas.92.19.8871. PMC 41069. PMID 7568034.
• Demetrick DJ, Matsumoto S, Hannon GJ, et al. (1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet. Cell Genet. 69 (3–4): 190–2. doi:10.1159/000133960. PMID 7698009.
• Yoshizumi M, Lee WS, Hsieh CM, et al. (1995). "Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts". J. Clin. Invest. 95 (5): 2275–80. doi:10.1172/JCI117918. PMC 295840. PMID 7738192.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Rickert P, Seghezzi W, Shanahan F, et al. (1996). "Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II". Oncogene. 12 (12): 2631–40. PMID 8700522.
• Li H, Lahti JM, Valentine M, et al. (1997). "Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors". Genomics. 32 (2): 253–9. doi:10.1006/geno.1996.0112. PMID 8833152.
• Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. doi:10.1128/MCB.17.4.1817. PMC 232028. PMID 9121429.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Neish AS, Anderson SF, Schlegel BP, et al. (1998). "Factors associated with the mammalian RNA polymerase II holoenzyme". Nucleic Acids Res. 26 (3): 847–53. doi:10.1093/nar/26.3.847. PMC 147327. PMID 9443979.
• Cho H, Orphanides G, Sun X, et al. (1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. 18 (9): 5355–63. doi:10.1128/MCB.18.9.5355. PMC 109120. PMID 9710619.
• Sun X, Zhang Y, Cho H, et al. (1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell. 2 (2): 213–22. doi:10.1016/S1097-2765(00)80131-8. PMID 9734358.
• Gu W, Malik S, Ito M, et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Mol. Cell. 3 (1): 97–108. doi:10.1016/S1097-2765(00)80178-1. PMID 10024883.
• Ito M, Yuan CX, Malik S, et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
• Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. doi:10.1038/19783. PMID 10235266. S2CID 204992765.
• Wang G, Cantin GT, Stevens JL, Berk AJ (2001). "Characterization of Mediator Complexes from HeLa Cell Nuclear Extract". Mol. Cell. Biol. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. PMC 87123. PMID 11416138.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3" (PDF). J. Biol. Chem. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
• Ueberham U, Hessel A, Arendt T (2003). "Cyclin C expression is involved in the pathogenesis of Alzheimer's disease". Neurobiol. Aging. 24 (3): 427–35. doi:10.1016/S0197-4580(02)00132-X. PMID 12600719. S2CID 12604491.

This article on a gene on human chromosome 6 is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Genes on human chromosome 6
• Human chromosome 6 gene stubs