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CD2BP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GYF, 1L2Z, 1SYX, 4BWS
Identifiers
Aliases	CD2BP2, FWP010, LIN1, PPP1R59, Snu40, U5-52K, CD2 (cytoplasmic tail) binding protein 2, CD2 cytoplasmic tail binding protein 2
External IDs	OMIM: 604470; MGI: 1917483; HomoloGene: 4455; GeneCards: CD2BP2; OMA:CD2BP2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p11.2 Start 30,350,773 bp End 30,355,308 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F3 Start 126,790,832 bp End 126,795,222 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii granulocyte left adrenal gland left adrenal cortex right adrenal gland right adrenal cortex islet of Langerhans beta cell left uterine tube gastric mucosa Top expressed in saccule otic placode otic vesicle ventricular zone dentate gyrus of hippocampal formation granule cell neural layer of retina ganglionic eminence granulocyte epiblast superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ribonucleoprotein complex binding protein binding Cellular component U5 snRNP nuclear speck U4/U6 x U5 tri-snRNP complex nucleus nucleoplasm fibrillar center cytoplasm cytosol Biological process negative regulation of phosphatase activity mRNA splicing, via spliceosome mRNA processing spliceosomal tri-snRNP complex assembly RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10421 70233 Ensembl ENSG00000169217 ENSMUSG00000042502 UniProt O95400 Q9CWK3 RefSeq (mRNA) NM_006110 NM_001243646 NM_001285905 NM_001285906 NM_001285907 NM_027353 NM_001357817 RefSeq (protein) NP_001230575 NP_006101 NP_001230575.1 NP_006101.1 NP_001272834 NP_001272835 NP_001272836 NP_081629 NP_001344746 Location (UCSC) Chr 16: 30.35 – 30.36 Mb Chr 7: 126.79 – 126.8 Mb PubMed search
Wikidata
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CD2 antigen cytoplasmic tail-binding protein 2 is a protein that in humans is encoded by the CD2BP2 gene.

Interactions

CD2BP2 has been shown to interact with CD2.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000169217 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000042502 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Nishizawa K, Freund C, Li J, Wagner G, Reinherz EL (Jan 1999). "Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation". Proc Natl Acad Sci U S A. 95 (25): 14897–902. doi:10.1073/pnas.95.25.14897. PMC 24547. PMID 9843987.
6. "Entrez Gene: CD2BP2 CD2 (cytoplasmic tail) binding protein 2".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Laggerbauer B, Liu S, Makarov E, et al. (2005). "The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation". RNA. 11 (5): 598–608. doi:10.1261/rna.2300805. PMC 1370748. PMID 15840814.
• Cohavy O, Zhou J, Ware CF, Targan SR (2005). "LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling". J. Immunol. 174 (2): 646–53. doi:10.4049/jimmunol.174.2.646. PMID 15634882.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kofler M, Heuer K, Zech T, Freund C (2004). "Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2". J. Biol. Chem. 279 (27): 28292–7. doi:10.1074/jbc.M402008200. PMID 15105431.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Freund C, Kühne R, Yang H, et al. (2003). "Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules". EMBO J. 21 (22): 5985–95. doi:10.1093/emboj/cdf602. PMC 137194. PMID 12426371.
• Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Freund C, Dötsch V, Nishizawa K, et al. (1999). "The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences". Nat. Struct. Biol. 6 (7): 656–60. doi:10.1038/10712. PMID 10404223. S2CID 19688996.

External links

• Human CD2BP2 genome location and CD2BP2 gene details page in the UCSC Genome Browser.

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