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CD300C
Identifiers
Aliases	CD300C, CLM-6, CMRF-35, CMRF-35A, CMRF35, CMRF35-A1, CMRF35A, CMRF35A1, IGSF16, LIR, CD300c molecule
External IDs	OMIM: 606786; MGI: 2153249; HomoloGene: 74580; GeneCards: CD300C; OMA:CD300C - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.1 Start 74,541,073 bp End 74,546,115 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 E2|11 80.57 cM Start 114,887,547 bp End 114,892,706 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood spleen upper lobe of left lung appendix right lung bone marrow right coronary artery Descending thoracic aorta Top expressed in stroma of bone marrow granulocyte spleen blood calvaria right lung lobe mesenteric lymph nodes tibiofemoral joint thymus seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process cellular defense response immune system process regulation of immune response signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10871 140497 Ensembl ENSG00000167850 ENSMUSG00000044811 UniProt Q08708 Q7TSN2 RefSeq (mRNA) NM_006678 NM_134158 RefSeq (protein) NP_006669 NP_598919 Location (UCSC) Chr 17: 74.54 – 74.55 Mb Chr 11: 114.89 – 114.89 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CMRF35-like molecule 6 (CLM-6) also known as CD300 antigen-like family member C (CD300c) is a protein that in humans is encoded by the CD300C gene.

The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000167850 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000044811 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jackson DG, Hart DN, Starling G, Bell JI (Jun 1992). "Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor". Eur J Immunol. 22 (5): 1157–63. doi:10.1002/eji.1830220508. PMID 1349532. S2CID 23437463.
6. Clark GJ, Green BJ, Hart DN (Aug 2000). "The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17". Tissue Antigens. 55 (2): 101–9. doi:10.1034/j.1399-0039.2000.550201.x. PMID 10746781.
7. ^ "Entrez Gene: CD300C CD300c molecule".

External links

• Human CD300C genome location and CD300C gene details page in the UCSC Genome Browser.

Further reading

• Clark GJ, Fitzpatrick S, Kuo B, Modra C, Jamriska L, Hart DN (2002). "CMRF-35A, CMRF-35H: potential new CD". J. Biol. Regul. Homeost. Agents. 16 (3): 233–5. PMID 12456026.
• Cannon JP, Haire RN, Litman GW (December 2002). "Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate". Nat. Immunol. 3 (12): 1200–7. doi:10.1038/ni849. PMID 12415263. S2CID 19367972.
• Clark GJ, Cooper B, Fitzpatrick S, Green BJ, Hart DN (May 2001). "The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family". Tissue Antigens. 57 (5): 415–23. doi:10.1034/j.1399-0039.2001.057005415.x. PMID 11556966.

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