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T-cell surface glycoprotein CD3 epsilon chain

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Protein-coding gene in the species Homo sapiens
CD3E
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1A81, 1SY6, 1XIW, 2ROL

Identifiers
AliasesCD3E, IMD18, T3E, TCRE, CD3e molecule, CD3epsilon, CD3 epsilon subunit of T-cell receptor complex
External IDsOMIM: 186830; MGI: 88332; HomoloGene: 586; GeneCards: CD3E; OMA:CD3E - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)
Chromosome 11 (human)Genomic location for CD3EGenomic location for CD3E
Band11q23.3Start118,304,730 bp
End118,316,175 bp
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)
Chromosome 9 (mouse)Genomic location for CD3EGenomic location for CD3E
Band9 A5.2|9 24.84 cMStart44,910,038 bp
End44,920,925 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • appendix

  • lymph node

  • spleen

  • blood

  • epithelium of colon

  • thymus

  • gallbladder

  • rectum

  • mucosa of transverse colon
Top expressed in
  • thymus

  • blood

  • morula

  • blastocyst

  • mesenteric lymph nodes

  • spleen

  • pharynx

  • subcutaneous adipose tissue

  • duodenum

  • jejunum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

916

12501

Ensembl

ENSG00000198851

ENSMUSG00000032093

UniProt

P07766

P22646

RefSeq (mRNA)

NM_000733

NM_007648

RefSeq (protein)

NP_000724

NP_031674

Location (UCSC)Chr 11: 118.3 – 118.32 MbChr 9: 44.91 – 44.92 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.

Function

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.

Clinical significance

Defects in this gene cause severe immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.

Interactions

T-cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B, CD3EAP and NCK2.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000198851Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000032093Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C (1986). "Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex". Nature. 321 (6068): 431–4. Bibcode:1986Natur.321..431G. doi:10.1038/321431a0. PMID 3012357. S2CID 4318166.
  6. Clevers HC, Dunlap S, Wileman TE, Terhorst C (November 1988). "Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter". Proceedings of the National Academy of Sciences of the United States of America. 85 (21): 8156–60. doi:10.1073/pnas.85.21.8156. PMC 282386. PMID 3267235.
  7. "Entrez Gene: CD3E CD3e molecule, epsilon (CD3-TCR complex)".
  8. Soudais C, de Villartay JP, Le Deist F, Fischer A, Lisowska-Grospierre B (January 1993). "Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency". Nature Genetics. 3 (1): 77–81. doi:10.1038/ng0193-77. PMID 8490660. S2CID 205341366.
  9. de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F (November 2004). "Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3". The Journal of Clinical Investigation. 114 (10): 1512–7. doi:10.1172/JCI22588. PMC 525745. PMID 15546002.
  10. Wong S, Moore S, Orisio S, Millward A, Demaine AG (January 1991). "Susceptibility to type I diabetes in women is associated with the CD3 epsilon locus on chromosome 11". Clinical and Experimental Immunology. 83 (1): 69–73. doi:10.1111/j.1365-2249.1991.tb05590.x. PMC 1535466. PMID 1671006.
  11. Nakano H, Yamazaki T, Miyatake S, Nozaki N, Kikuchi A, Saito T (March 1996). "Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex". The Journal of Biological Chemistry. 271 (11): 6483–9. doi:10.1074/jbc.271.11.6483. PMID 8626450.
  12. Yamazaki T, Hamano Y, Tashiro H, Itoh K, Nakano H, Miyatake S, Saito T (June 1999). "CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells". The Journal of Biological Chemistry. 274 (26): 18173–80. doi:10.1074/jbc.274.26.18173. PMID 10373416.
  13. Gil D, Schamel WW, Montoya M, Sánchez-Madrid F, Alarcón B (June 2002). "Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation". Cell. 109 (7): 901–12. doi:10.1016/S0092-8674(02)00799-7. PMID 12110186. S2CID 2714623.

Further reading

PDB gallery
  • 1xiw: Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment 1xiw: Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50
51–100
101–150
151–200
201–250
251–300
301–350

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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