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Protein domain
Protein family
CDC48_N
crystal structure of aaa atpase p97/vcp nd1 in complex with p47 c
In molecular biology, the CDC48 N-terminal domain is a protein domain found in AAA ATPases including cell division protein 48 (CDC48), VCP-like ATPase and N-ethylmaleimide sensitive fusion protein. It is a substrate recognition domain which binds polypeptides, prevents protein aggregation, and catalyses refolding of permissive substrates. It is composed of two equally sized subdomains. The amino-terminal subdomain (CDC48_N) forms a double-psi beta-barrel whose pseudo-twofold symmetry is mirrored by an internal sequencerepeat of 42 residues. The carboxy-terminal subdomain (CDC48_2) forms a novel six-stranded beta-clam fold. Together these subdomains form a kidney-shaped structure, in close agreement with results from electron microscopy. CDC48_N is related to numerous proteins including prokaryotictranscription factors, metabolic enzymes, the proteasecofactors UFD1 and PrlF, and aspartic proteinases.
crystal structure of aaa atpase p97/vcp nd1 in complex with p47 c
amino terminal domain of the n-ethylmaleimide sensitive fusion protein (nsf)