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CDCA3
Identifiers
Aliases	CDCA3, GRCC8, TOME-1, cell division cycle associated 3, TOME1
External IDs	OMIM: 607749; MGI: 1315198; HomoloGene: 8403; GeneCards: CDCA3; OMA:CDCA3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.31 Start 6,844,793 bp End 6,851,292 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 F2|6 59.17 cM Start 124,806,510 bp End 124,810,664 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone oocyte secondary oocyte gonad left testis right testis ganglionic eminence duodenum jejunal mucosa mucosa of transverse colon Top expressed in ventricular zone fetal liver hematopoietic progenitor cell medial ganglionic eminence genital tubercle tibiofemoral joint spermatid tail of embryo seminiferous tubule spermatocyte abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytosol cytoplasm Biological process cell division cell cycle protein ubiquitination biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83461 14793 Ensembl ENSG00000111665 ENSMUSG00000023505 UniProt Q99618 Q99M54 RefSeq (mRNA) NM_001297602 NM_001297603 NM_001297604 NM_031299 NM_001331019 NM_013538 RefSeq (protein) NP_001284531 NP_001284532 NP_001284533 NP_001317948 NP_112589 NP_038566 Location (UCSC) Chr 12: 6.84 – 6.85 Mb Chr 6: 124.81 – 124.81 Mb PubMed search
Wikidata
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Cell division cycle-associated protein 3 is a protein that in humans is encoded by the CDCA3 gene.

Interactions

CDCA3 has been shown to interact with SKP1A.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000111665 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000023505 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA (May 1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Res. 7 (3): 268–80. doi:10.1101/gr.7.3.268. PMID 9074930.
6. Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
7. "Entrez Gene: CDCA3 cell division cycle associated 3".
8. Ayad, Nagi G; Rankin Susannah; Murakami Monica; Jebanathirajah Judith; Gygi Steven; Kirschner Marc W (Apr 2003). "Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC". Cell. 113 (1). United States: 101–13. doi:10.1016/S0092-8674(03)00232-0. ISSN 0092-8674. PMID 12679038.

External links

• Human CDCA3 genome location and CDCA3 gene details page in the UCSC Genome Browser.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Yoshida K (2005). "Cell-cycle-dependent regulation of the human and mouse Tome-1 promoters". FEBS Lett. 579 (6): 1488–92. doi:10.1016/j.febslet.2005.01.055. PMID 15733861. S2CID 19511881.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ayad NG, Rankin S, Murakami M, et al. (2003). "Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC". Cell. 113 (1): 101–13. CiteSeerX 10.1.1.522.1877. doi:10.1016/S0092-8674(03)00232-0. PMID 12679038.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ansari-Lari MA, Muzny DM, Lu J, et al. (1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res. 6 (4): 314–26. doi:10.1101/gr.6.4.314. PMID 8723724.

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