CDP-glucose 4,6-dehydratase | |||||||||
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Identifiers | |||||||||
EC no. | 4.2.1.45 | ||||||||
CAS no. | 37259-55-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme CDP-glucose 4,6-dehydratase (EC 4.2.1.45) catalyzes the chemical reaction
- CDP-glucose CDP-4-dehydro-6-deoxy-D-glucose + H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. This enzyme participates in starch and sucrose metabolism. It employs one cofactor, NAD.
Nomenclature
The systematic name of this enzyme class is CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming). Other names in common use include:
- cytidine diphosphoglucose oxidoreductase, and
- CDP-glucose 4,6-hydro-lyase.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1RKX and 1WVG.
References
- Hey AE, Elbein AD (1966). "Biosynthesis of tyvelose. The purification and properties of cytidine diphosphate D-glucose oxidoreductase". J. Biol. Chem. 241 (22): 5473–8. doi:10.1016/S0021-9258(18)96454-9. PMID 4380946.
- Matsuhashi S, Matsuhashi M, Brown JG, Strominger JL (1966). "Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 3 Cytidine diphosphate D-glucose oxidoreductase". J. Biol. Chem. 241 (18): 4283–7. doi:10.1016/S0021-9258(18)99780-2. PMID 4288651.
- Melo A, Elliott WH, Glaser L (1968). "The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase". J. Biol. Chem. 243 (7): 1467–74. doi:10.1016/S0021-9258(18)93566-0. PMID 4869560.
Carbon–oxygen lyases (EC 4.2) (primarily dehydratases) | |
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4.2.1: Hydro-Lyases | |
4.2.2: Acting on polysaccharides | |
4.2.3: Acting on phosphates | |
4.2.99: Other |
Enzymes | |
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Activity | |
Regulation | |
Classification | |
Kinetics | |
Types |
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