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CEP57
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4L0R
Identifiers
Aliases	CEP57, MVA2, PIG8, TSP57, centrosomal protein 57
External IDs	OMIM: 607951; MGI: 1915551; HomoloGene: 8790; GeneCards: CEP57; OMA:CEP57 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q21 Start 95,789,965 bp End 95,832,693 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A1 Start 13,719,088 bp End 13,738,403 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte Achilles tendon sperm ganglionic eminence secondary oocyte gallbladder hair follicle ventricular zone Epithelium of choroid plexus cartilage tissue Top expressed in seminiferous tubule hand spermatid genital tubercle tail of embryo spermatocyte ventricular zone epiblast abdominal wall thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity microtubule binding protein binding identical protein binding fibroblast growth factor binding gamma-tubulin binding Cellular component cytosol centrosome Golgi apparatus microtubule organizing center microtubule cytoskeleton nucleus cytoplasm microtubule cytoskeleton nucleoplasm Biological process fibroblast growth factor receptor signaling pathway microtubule anchoring G2/M transition of mitotic cell cycle spermatid development mitotic sister chromatid segregation protein homooligomerization ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9702 74360 Ensembl ENSG00000166037 ENSMUSG00000031922 UniProt Q86XR8 Q8CEE0 RefSeq (mRNA) NM_001243776 NM_001243777 NM_014679 NM_001363604 NM_026665 NM_001310721 RefSeq (protein) NP_001230705 NP_001230706 NP_055494 NP_001350533 NP_001297650 NP_080941 Location (UCSC) Chr 11: 95.79 – 95.83 Mb Chr 9: 13.72 – 13.74 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Centrosomal protein of 57 kDa is a protein that in humans is encoded by the CEP57 gene. It is also known as translokin.

Translokin binds basic fibroblast growth factor (FGF2; MIM 134920) and mediates its nuclear translocation and mitogenic activity (Bossard et al., 2003).

References

1. ^ GRCh38: Ensembl release 89: ENSG00000166037 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000031922 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
6. ^ "Entrez Gene: CEP57 centrosomal protein 57kDa".

External links

• Human CEP57 genome location and CEP57 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 57 kDa

Further reading

• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bossard C, Laurell H, Van den Berghe L, et al. (2003). "Translokin is an intracellular mediator of FGF-2 trafficking". Nat. Cell Biol. 5 (5): 433–9. doi:10.1038/ncb979. PMID 12717444. S2CID 21792653.
• Kim YS, Nakanishi G, Oudes AJ, et al. (2004). "Tsp57: a novel gene induced during a specific stage of spermatogenesis". Biol. Reprod. 70 (1): 106–13. doi:10.1095/biolreprod.103.018465. PMID 12954732.
• Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ahn J, Chung KS, Kim DU, et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus". J. Biochem. Mol. Biol. 37 (6): 741–8. doi:10.5483/bmbrep.2004.37.6.741. PMID 15607035.

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