Misplaced Pages

CLC (gene)

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Protein-coding gene in the species Homo sapiens

CLC
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

1G86, 1HDK, 1LCL, 1QKQ

Identifiers
AliasesCLC, GAL10, Gal-10, LGALS10, LGALS10A, LPPL_HUMAN, Charcot-Leyden crystal galectin, galectin-10
External IDsOMIM: 153310; HomoloGene: 130498; GeneCards: CLC; OMA:CLC - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)
Chromosome 19 (human)Genomic location for CLCGenomic location for CLC
Band19q13.2Start39,731,255 bp
End39,738,029 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • trabecular bone

  • bone marrow

  • bone marrow cells

  • testicle

  • monocyte

  • blood

  • gallbladder

  • appendix

  • granulocyte

  • mucosa of transverse colon
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1178

n/a

Ensembl

ENSG00000105205

n/a

UniProt

Q05315

n/a

RefSeq (mRNA)

NM_001828

n/a

RefSeq (protein)

NP_001819

n/a

Location (UCSC)Chr 19: 39.73 – 39.74 Mbn/a
PubMed searchn/a
Wikidata
View/Edit Human

Galectin-10 is an enzyme that in humans is encoded by the CLC gene.

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000105205Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ (Jun 1992). "Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14". Genomics. 13 (1): 240–2. doi:10.1016/0888-7543(92)90237-M. PMID 1577491.
  4. ^ "CLC Charcot-Leyden crystal galectin [ Homo sapiens (human) ]".

Further reading

External links

PDB gallery
  • 1g86: CHARCOT-LEYDEN CRYSTAL PROTEIN/N-ETHYLMALEIMIDE COMPLEX 1g86: CHARCOT-LEYDEN CRYSTAL PROTEIN/N-ETHYLMALEIMIDE COMPLEX
  • 1hdk: CHARCOT-LEYDEN CRYSTAL PROTEIN - PCMBS COMPLEX 1hdk: CHARCOT-LEYDEN CRYSTAL PROTEIN - PCMBS COMPLEX
  • 1lcl: CHARCOT-LEYDEN CRYSTAL PROTEIN 1lcl: CHARCOT-LEYDEN CRYSTAL PROTEIN
  • 1qkq: CHARCOT-LEYDEN CRYSTAL PROTEIN - MANNOSE COMPLEX 1qkq: CHARCOT-LEYDEN CRYSTAL PROTEIN - MANNOSE COMPLEX


Stub icon

This article on a gene on human chromosome 19 is a stub. You can help Misplaced Pages by expanding it.

Categories: