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COG4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HR0
Identifiers
Aliases	COG4, CDG2J, COD1, component of oligomeric golgi complex 4, SWILS
External IDs	OMIM: 606976; MGI: 2142808; HomoloGene: 7155; GeneCards: COG4; OMA:COG4 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.1 Start 70,480,568 bp End 70,523,560 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 E1|8 57.76 cM Start 111,573,232 bp End 111,608,859 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon apex of heart muscle of thigh right testis granulocyte gastrocnemius muscle rectum left testis ventricular zone right adrenal gland Top expressed in interventricular septum spermatocyte spermatid internal carotid artery muscle of thigh external carotid artery facial motor nucleus skeletal muscle tissue right kidney proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding Cellular component Golgi transport complex Golgi membrane Golgi apparatus membrane trans-Golgi network membrane cytoplasm cytosol Biological process protein transport endoplasmic reticulum to Golgi vesicle-mediated transport retrograde transport, vesicle recycling within Golgi Golgi vesicle prefusion complex stabilization retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Golgi organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25839 102339 Ensembl ENSG00000103051 ENSMUSG00000031753 UniProt Q9H9E3 Q8R1U1 RefSeq (mRNA) NM_001195139 NM_015386 NM_001365426 NM_145818 NM_133973 NM_001310607 RefSeq (protein) NP_001182068 NP_056201 NP_001352355 NP_001297536 NP_598734 Location (UCSC) Chr 16: 70.48 – 70.52 Mb Chr 8: 111.57 – 111.61 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Conserved oligomeric Golgi complex subunit 4 is a protein that in humans is encoded by the COG4 gene.

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG4 (Ungar et al., 2002).

Interactions

COG4 has been shown to interact with COG7, COG2, COG1 and COG5.

Clinical

Mutations in this gene have been associated with Saul-Wilson syndrome.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000103051 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000031753 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
6. ^ "Entrez Gene: COG4 component of oligomeric golgi complex 4".
7. ^ Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23). United States: 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.
8. Ferreira C (2020) Saul-Wilson syndrome. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. SourceGeneReviews. Seattle (WA): University of Washington, Seattle

Further reading

• Whyte JR, Munro S (2001). "The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic". Dev. Cell. 1 (4): 527–37. doi:10.1016/S1534-5807(01)00063-6. PMID 11703943.
• Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
• Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. PMID 15047703.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
• Human COG4 genome location and COG4 gene details page in the UCSC Genome Browser.

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