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CPSF6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3P5T, 3P6Y, 3Q2S, 3Q2T, 4B4N, 4U0A, 4U0B, 4WYM
Identifiers
Aliases	CPSF6, CFIM, CFIM68, HPBRII-4, HPBRII-7, cleavage and polyadenylation specific factor 6, CFIM72
External IDs	OMIM: 604979; MGI: 1913948; HomoloGene: 134126; GeneCards: CPSF6; OMA:CPSF6 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q15 Start 69,239,569 bp End 69,274,358 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 D2 Start 117,180,578 bp End 117,215,920 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence bone marrow cells Achilles tendon ventricular zone tonsil left ovary right ovary appendix sural nerve endometrium Top expressed in superior cervical ganglion hand otolith organ utricle mandibular prominence cumulus cell trigeminal ganglion maxillary prominence abdominal wall ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding mRNA binding RNA binding nucleic acid binding ribosomal large subunit binding exon-exon junction complex binding Cellular component paraspeckles membrane nucleus nucleoplasm nuclear speck mRNA cleavage factor complex perichromatin fibrils cytoplasm mRNA cleavage and polyadenylation specificity factor complex interchromatin granule ribonucleoprotein complex Biological process mRNA polyadenylation mRNA processing protein tetramerization positive regulation of RNA export from nucleus protein heterotetramerization pre-mRNA cleavage required for polyadenylation mRNA alternative polyadenylation messenger ribonucleoprotein complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11052 432508 Ensembl ENSG00000111605 ENSMUSG00000055531 UniProt Q16630 Q6NVF9 RefSeq (mRNA) NM_001300947 NM_007007 NM_001013391 NM_001310609 RefSeq (protein) NP_001287876 NP_008938 NP_001013409 NP_001297538 Location (UCSC) Chr 12: 69.24 – 69.27 Mb Chr 10: 117.18 – 117.22 Mb PubMed search
Wikidata
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Cleavage and polyadenylation specificity factor subunit 6 is a protein that in humans is encoded by the CPSF6 gene.

Function

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.

Interactions

CPSF6 has been shown to interact with WWP1 and PLSCR1.

CPSF6 plays an important role in the nuclear import and integration of HIV-1 capsids.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000111605 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000055531 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rüegsegger U, Blank D, Keller W (Jan 1998). "Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits". Molecular Cell. 1 (2): 243–53. doi:10.1016/S1097-2765(00)80025-8. PMID 9659921.
6. Cardinale S, Cisterna B, Bonetti P, Aringhieri C, Biggiogera M, Barabino SM (Apr 2007). "Subnuclear localization and dynamics of the Pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit". Molecular Biology of the Cell. 18 (4): 1282–92. doi:10.1091/mbc.E06-09-0846. PMC 1838998. PMID 17267687.
7. ^ "Entrez Gene: CPSF6 cleavage and polyadenylation specific factor 6, 68kDa".
8. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
9. Müller TG, Zila V, Müller B, Kräusslich HG (29 September 2022). "Nuclear Capsid Uncoating and Reverse Transcription of HIV-1". Annual Review of Virology. 9 (1): 261–284. doi:10.1146/annurev-virology-020922-110929. PMID 35704745.

External links

• Human CPSF6 genome location and CPSF6 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Rüegsegger U, Beyer K, Keller W (Mar 1996). "Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors". The Journal of Biological Chemistry. 271 (11): 6107–13. doi:10.1074/jbc.271.11.6107. PMID 8626397.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• de Vries H, Rüegsegger U, Hübner W, Friedlein A, Langen H, Keller W (Nov 2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors". The EMBO Journal. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMC 305781. PMID 11060040.
• Awasthi S, Alwine JC (Nov 2003). "Association of polyadenylation cleavage factor I with U1 snRNP". RNA. 9 (11): 1400–9. doi:10.1261/rna.5104603. PMC 1287061. PMID 14561889.
• Brown KM, Gilmartin GM (Dec 2003). "A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im". Molecular Cell. 12 (6): 1467–76. doi:10.1016/S1097-2765(03)00453-2. PMID 14690600.
• Dettwiler S, Aringhieri C, Cardinale S, Keller W, Barabino SM (Aug 2004). "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization" (PDF). The Journal of Biological Chemistry. 279 (34): 35788–97. doi:10.1074/jbc.M403927200. PMID 15169763. S2CID 39752996.
• Venkataraman K, Brown KM, Gilmartin GM (Jun 2005). "Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition". Genes & Development. 19 (11): 1315–27. doi:10.1101/gad.1298605. PMC 1142555. PMID 15937220.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Millevoi S, Loulergue C, Dettwiler S, Karaa SZ, Keller W, Antoniou M, Vagner S (Oct 2006). "An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries". The EMBO Journal. 25 (20): 4854–64. doi:10.1038/sj.emboj.7601331. PMC 1618107. PMID 17024186.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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