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CRYZ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YB5
Identifiers
Aliases	CRYZ, crystallin zeta
External IDs	OMIM: 123691; MGI: 88527; HomoloGene: 133907; GeneCards: CRYZ; OMA:CRYZ - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p31.1 Start 74,705,482 bp End 74,733,408 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 H4 Start 154,596,711 bp End 154,623,182 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte renal medulla kidney tubule right lobe of liver corpus epididymis caput epididymis seminal vesicula gallbladder body of pancreas human kidney Top expressed in retinal pigment epithelium human kidney right kidney Epithelium of choroid plexus left lobe of liver iris pineal gland epithelium of lens ciliary body vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity zinc ion binding NADPH binding NADPH:quinone reductase activity NADH binding RNA binding mRNA 3'-UTR binding Cellular component cytosol extracellular exosome cytoplasm Biological process protein homotetramerization xenobiotic catabolic process visual perception Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1429 12972 Ensembl ENSG00000116791 ENSMUSG00000028199 UniProt Q08257 P47199 RefSeq (mRNA) NM_001130042 NM_001130043 NM_001134759 NM_001889 NM_009968 RefSeq (protein) NP_001123514 NP_001123515 NP_001128231 NP_001880 NP_034098 NP_001344601 NP_001344602 NP_001344603 NP_001344604 NP_001344605 Location (UCSC) Chr 1: 74.71 – 74.73 Mb Chr 3: 154.6 – 154.62 Mb PubMed search
Wikidata
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Quinone oxidoreductase is an enzyme that in humans is encoded by the CRYZ gene.

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. One pseudogene is known to exist.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000116791 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028199 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: CRYZ crystallin, zeta (quinone reductase)".

External links

• Human CRYZ genome location and CRYZ gene details page in the UCSC Genome Browser.

Further reading

• Heinzmann C, Kojis TL, Gonzalez P, et al. (1995). "Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms". Genomics. 23 (2): 403–7. doi:10.1006/geno.1994.1516. PMID 7835889.
• Gonzalez P, Rao PV, Zigler JS (1994). "Organization of the human zeta-crystallin/quinone reductase gene (CRYZ)". Genomics. 21 (2): 317–24. doi:10.1006/geno.1994.1272. PMID 8088825.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Gonzalez P, Rao PV, Zigler JS (1993). "Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver". Biochem. Biophys. Res. Commun. 191 (3): 902–7. doi:10.1006/bbrc.1993.1302. PMID 8466529.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wang W, Liu LQ, Higuchi CM, Chen H (1998). "Induction of NADPH:quinone reductase by dietary phytoestrogens in colonic Colo205 cells". Biochem. Pharmacol. 56 (2): 189–95. doi:10.1016/S0006-2952(98)00141-5. PMID 9698072.
• Goenka S, Raman B, Ramakrishna T, Rao CM (2001). "Unfolding and refolding of a quinone oxidoreductase: alpha-crystallin, a molecular chaperone, assists its reactivation". Biochem. J. 359 (Pt 3): 547–56. doi:10.1042/0264-6021:3590547. PMC 1222175. PMID 11672428.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bianco NR, Perry G, Smith MA, et al. (2004). "Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage". Mol. Endocrinol. 17 (7): 1344–55. doi:10.1210/me.2002-0382. PMID 12714703.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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