CRZ1, short for Calcineurin-Responsive Zinc Finger 1, is a transcription factor that regulates calcineurin dependent-genes in Candida albicans.
Mechanism of action
The cytoplasmic protein Crz1 is dephosphorylated by the calcineurin and is then targeted to the nucleus. The nuclear protein activates the transcription of genes involved in cell-wall maintenance and ion homeostasis.
Structure
The protein Crz1 possesses a Zinc-Finger motif that binds to a specific motif called CDRE (Calcineurin-Dependent Response Element) present on the promoter of the targeted genes. It also possesses a nuclear localization signal (NLS) at the N-terminal part
References
- ^ Steinbach, William J.; Reedy, Jennifer L.; Cramer, Robert A.; Perfect, John R.; Heitman, Joseph (June 2007). "Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections". Nature Reviews. Microbiology. 5 (6): 418–430. doi:10.1038/nrmicro1680. ISSN 1740-1534. PMID 17505522. S2CID 28292376.
- Stathopoulos-Gerontides, A.; Guo, J. J.; Cyert, M. S. (1999-04-01). "Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation". Genes & Development. 13 (7): 798–803. doi:10.1101/gad.13.7.798. ISSN 0890-9369. PMC 316598. PMID 10197980.
- ^ Stathopoulos, A. M.; Cyert, M. S. (1997-12-15). "Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast". Genes & Development. 11 (24): 3432–3444. doi:10.1101/gad.11.24.3432. ISSN 0890-9369. PMC 316814. PMID 9407035.
- Karababa, Mahir; Valentino, Emilio; Pardini, Giacomo; Coste, Alix T.; Bille, Jacques; Sanglard, Dominique (March 2006). "CRZ1, a target of the calcineurin pathway in Candida albicans: Calcineurin targets in Candida albicans". Molecular Microbiology. 59 (5): 1429–1451. doi:10.1111/j.1365-2958.2005.05037.x. PMID 16468987.