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CTBS
Identifiers
Aliases	CTBS, CTB, chitobiase
External IDs	OMIM: 600873; MGI: 1921495; HomoloGene: 3231; GeneCards: CTBS; OMA:CTBS - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p22.3 Start 84,549,611 bp End 84,574,480 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 H2 Start 146,155,550 bp End 146,171,604 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Epithelium of choroid plexus monocyte retinal pigment epithelium blood islet of Langerhans stromal cell of endometrium right lobe of liver olfactory zone of nasal mucosa Descending thoracic aorta ascending aorta Top expressed in proximal tubule right kidney granulocyte human kidney secondary oocyte decidua medullary collecting duct liver efferent ductule primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity hydrolase activity, acting on glycosyl bonds chitinase activity chitin binding Cellular component lysosome extracellular exosome extracellular space Biological process oligosaccharide catabolic process metabolism chitin catabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1486 74245 Ensembl ENSG00000117151 ENSMUSG00000028189 UniProt Q01459 Q8R242 RefSeq (mRNA) NM_004388 NM_001293672 NM_028836 RefSeq (protein) NP_004379 NP_001280601 NP_083112 Location (UCSC) Chr 1: 84.55 – 84.57 Mb Chr 3: 146.16 – 146.17 Mb PubMed search
Wikidata
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Di-N-acetylchitobiase is an enzyme that in humans is encoded by the CTBS gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000117151 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028189 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fisher KJ, Aronson NN Jr (Apr 1992). "Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5)". Mol Cell Biol. 12 (4): 1585–91. doi:10.1128/mcb.12.4.1585. PMC 369601. PMID 1549114.
6. Ahmad W, Li S, Chen H, Tuck-Muller CM, Pittler SJ, Aronson NN Jr (Aug 1995). "Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22". Cytogenet Cell Genet. 71 (1): 44–6. doi:10.1159/000134059. PMID 7606925.
7. "Entrez Gene: CTBS chitobiase, di-N-acetyl-".

External links

• Human CTBS genome location and CTBS gene details page in the UCSC Genome Browser.

Further reading

• Aronson NN, Halloran BA (2006). "Optimum substrate size and specific anomer requirements for the reducing-end glycoside hydrolase di-N-acetylchitobiase". Biosci. Biotechnol. Biochem. 70 (6): 1537–41. doi:10.1271/bbb.60183. PMID 16794344. S2CID 1848335.
• Kamioka Y, Fukuhara S, Sawa H, et al. (2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". J. Biol. Chem. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hutchinson T, Dwivedi K, Rastogi A, et al. (2002). "N-acetyl beta-D-glucosaminidase is not attached to human sperm membranes through the glycosylphosphatidyl inositol (GPI)-anchor". Asian J. Androl. 4 (1): 27–33. PMID 11907625.
• Liu B, Ahmad W, Aronson NN (1999). "Structure of the human gene for lysosomal di-N-acetylchitobiase". Glycobiology. 9 (6): 589–93. doi:10.1093/glycob/9.6.589. PMID 10336991.
• Aronson NN, Backes M, Kuranda MJ (1989). "Rat liver chitobiase: purification, properties, and role in the lysosomal degradation of Asn-linked glycoproteins". Arch. Biochem. Biophys. 272 (2): 290–300. doi:10.1016/0003-9861(89)90222-1. PMID 2751306.
• Fisher KJ, Aronson NN (1992). "Cloning and expression of the cDNA sequence encoding the lysosomal glycosidase di-N-acetylchitobiase". J. Biol. Chem. 267 (27): 19607–16. doi:10.1016/S0021-9258(18)41818-2. PMID 1527079.

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