A caboose is a crewed railroad car at the end of a freight train in North America.
Caboose may also refer to:
- Caboose (ship's galley), a ship's kitchen above deck
- Caboose (Red vs. Blue), a character in the video series Red vs. Blue
- Caboose (film), a 1996 Canadian film directed by Richard Roy
- "Caboose", a song by Sugar Ray from Lemonade and Brownies
- Mrs. Crabbople's Caboose a children's television series, with set design, and puppetry by Wayne White (artist), shortly before working on Pee-wee's Playhouse.
Use as slang
- A slang for Buttocks, due to a caboose being the "rear end" of a train
- A slang for Bustle, which is a padded undergarment used to add fullness, or support the drapery, at the back of women's dresses in the mid-to-late 19th century.
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