Cacace is a surname. Notable people with the surname include:
- Alejandro Cacace (born 1985), Argentine politician
- Anthony Cacace (born 1989), Irish boxer
- Ezequiel Cacace (born 1984), Argentine football goalkeeper
- Flavia Cacace (born 1980), Italian-born British dancer
- Fulvio Cacace (?–2003), Italian chemist
- Joel Cacace (born 1941), New York City mobster
- Liberato Cacace (born 2000), New Zealand soccer player
See also
- Kachalsky v. Cacace , 2012 lawsuit
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