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Calx-beta
first ca2+ binding domain of the na,ca-exchanger (ncx1)
Identifiers
Symbol	Calx-beta
Pfam	PF03160
InterPro	IPR003644
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, the calx-beta motif is a protein motif which is present as a tandem repeat in the cytoplasmic domains of Calx sodium-calcium exchangers, which are used to expel calcium from cells. This motif overlaps domains used for calcium binding and regulation. The calx-beta motif is also present in the cytoplasmic tail of mammalian integrin-beta4, which mediates the bi-directional transfer of signals across the plasma membrane, as well as in some cyanobacterial proteins. This motif contains a series of beta-strands and turns that form a self-contained beta-sheet.

References

1. Schwarz EM, Benzer S (September 1997). "Calx, a Na-Ca exchanger gene of Drosophila melanogaster". Proceedings of the National Academy of Sciences of the United States of America. 94 (19): 10249–54. Bibcode:1997PNAS...9410249S. doi:10.1073/pnas.94.19.10249. PMC 23348. PMID 9294196.
2. Schwarz E, Benzer S (July 1999). "The recently reported NIbeta domain is already known as the Calx-beta motif". Trends in Biochemical Sciences. 24 (7): 260. doi:10.1016/S0968-0004(99)01422-X. PMID 10390612.

• Protein domains