Candidapepsin

Identifiers

Databases

IntEnz

IntEnz view

PDB structures

Search
PMC	articles
PubMed	articles
NCBI	proteins

Candidapepsin (EC 3.4.23.24, Candida albicans aspartic proteinase, Candida albicans carboxyl proteinase, Candida albicans secretory acid proteinase, Candida olea acid proteinase, Candida aspartic proteinase, Candida olea aspartic proteinase) is an enzyme. This enzyme catalyses the following chemical reaction

Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave Leu-Tyr, Tyr-Leu and Phe-Phe of insulin B chain. Activates trypsinogen, and degrades keratin

This endopeptidase is present in yeast Candida albicans.

References

Remold H, Fasold H, Staib F (October 1968). "Purification and characterization of a proteolytic enzyme from Candida albicans". Biochimica et Biophysica Acta (BBA) - Enzymology. 167 (2): 399–406. doi:10.1016/0005-2744(68)90219-2. PMID 5729955.
Rüchel R (May 1981). "Properties of a purified proteinase from the yeast Candida albicans". Biochimica et Biophysica Acta (BBA) - Enzymology. 659 (1): 99–113. doi:10.1016/0005-2744(81)90274-6. PMID 7018586.
Negi M, Tsuboi R, Matsui T, Ogawa H (July 1984). "Isolation and characterization of proteinase from Candida albicans: substrate specificity". The Journal of Investigative Dermatology. 83 (1): 32–6. doi:10.1111/1523-1747.ep12261656. PMID 6203988.
Lott TJ, Page LS, Boiron P, Benson J, Reiss E (February 1989). "Nucleotide sequence of the Candida albicans aspartyl proteinase gene". Nucleic Acids Research. 17 (4): 1779. doi:10.1093/nar/17.4.1779. PMC 331855. PMID 2646602.

External links

Candidapepsin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Proteases: aspartate proteases (EC 3.4.23)
Vertebrate	Pepsin Chymosin Renin Signal peptide peptidase Beta secretase 1 2
Pathogenic	Plasmepsin HIV-1 protease
Plant	Nepenthesin
Cathepsin	D E

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 3.4.23