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New F2s Toby De Silva and Ruth Winters arrive for their first shift in the Emergency Department. Toby makes several initial mistakes with one being letting a patient that has overdosed on paracetamol and another being that he fails to insert a simple IV line after 6 years of training. He is then sent out with Dixie when a bomb on a bus explodes on a busy main road. He then realises that the shop that was affected was the same shop as he visited on his way to work. He is then forced to assist Maggie in amputating a lad's arm to save his mother's life. Toby questions his decision to become a doctor and almost quits, when he saves the life of a young diabetic girl caught up in the explosion.

Note: First appearance of Ruth Winters and Toby De Silva as F2 Doctors

Selena and Nathan's baby is recovering in the ED, Angel, has been off the ventilator for the past day. Meanwhile a young mother breaks into a house in order to get her baby but the grandmother confronts her on her escape and she suffers a head injury as the mother escapes. The mother is pursued by the father and when she hides, the baby starts screaming she covers his mouth and nose to keep him quiet and hides him in a cement mixer. She then beats the father after he tries to tackle her, he is rendered unconscious. Meanwhile new consultant, Adam Trueman is out for a run when he sees the young mother about to commit suicide off the bridge. He successfully manages to talk her out of it by telling her how she would regret it. Meanwhile the daughter of one of Guppy's patients who died is desperate to speak to him but he gives her the cold shoulder and demands that Alice deals with it, much to Charlie's disgust. Nathan baby's heart keeps stopping so she is put back onto the ventilator, in order to take the strain off of the premature baby's heart. The doctors suggest taking her off the machine after all of her organs are failing after getting an e coli infection. Guppy makes a serious mistake after missing treatment steps in a boy's dislocated ankle, while Ruth had told him what had to be done previously. The psychotic mother escapes after Guppy confronts the grieving daughter. The witness to the attempted suicide that Adam attended turns out to be a reporter trying to get an inside scoop by using Adam. Guppy hands in his hospital pass saying that he is unfit to practice.

Somebody from the department has been talking to the press about the departments affairs during the bombing that happened in episodes 1 and 2. Harry Harper makes a statement on the news about the news report, defending the department. Meanwhile while driving to the music studio a man spills his coffee over his legs while driving causing him to crash his car. It transpires that his daughter, Susie, was in the boot of the van and was seriously injured in the accident. New receptionist T.C fools Nadia pretending to be a priest when Tess catches him out and gives him a final warning on his first day. Marilyn Fox is dealing with the inquiry and while she interviews Nathan, he blames Charlie for the events and brings up the incident where Charlie prescribed a patient medicine which caused her to have an anaphylactic shock. Alice then confronts Adam about how the press found the information to which he confesses to but Tess covers for him. Guppy confides in Harry about his drug use to which Harry tries to assure Guppy that he can seek help. Susie crashes from an allergic reaction to the medicine, Adam successfully does a surgical airway and then she is transported up to theatre. The trust requests for Nathan Spencer to resign due to the outcome of the inquiry.

While Guppy awaits a train into Holby a young boy gets his arm stuck in a grate on the railway line, with a train approaching his only option is to break the boy's arm and pull him free to save his life. Once in the hospital the mother threatens to sue Guppy about how he broke her son's arm. Guppy then fails to manoeuvre the bone into position to allow the blood to flow so Kelsey and Maggie are forced to intervene. Meanwhile an elderly lady from the train is brought in and Toby is assigned to deal with her. After attempting to treat her with Adam's guidance, he once again fails to successfully remove blood from her artery therefore Ruth decides to step in. The mother slaps Nathan after he tells her to take her domestic home with her, Nathan calls the police on her and gets her removed from the department even though her boy is deteriorating in recess for some reason that Guppy can't seem to work out. Guppy then successfully comes to the conclusion that he is a hemophiliac and that the bruises are a symptom and not from his mother or bullies. The boys brain bleed needs a bore hole operation, the surgeons are busy and Maggie attempts her first ever bore hole with Guppy's guidance as Adam is out on a date and not available to come in. Guppy takes over from Maggie after one failed attempt and tells her she can't continue with her shaky hands. Josh's friends from the previous season, Davika and her daughter, are back for plastic surgery, Charlie comes across as implying that they shouldn't be in the country and won't pay Josh back which infuriates Josh. Guppy decides that he will still leave the ED even after having a successful day. Harry returns as the new Consultant manager much to everyone's, especially Nathan's, shock.The train and station scenes were filmed on location at Wirksworth on the Ecclesbourne Valley Railway.

With Harry's first day back in the ED under his new duties, he is quick to work with helping Toby out with his cases. Harry is ordered to fire Nathan by his superiors, much to Harry's outrage due to his recent losses. Meanwhile during an Army training exercise with live ammo, a medic is hit from behind with a bullet. Nathan slips on spilled coffee banging his head. While Harry is treating Nathan he tells him that he no longer has a job with which Nathan takes in his stride. The soldier collapses after his superior officer tampers with the machines. Ruth forgets to take a simple pregnancy test on a patient and when it looks like this will have repercussions on her when it turns out that she is pregnant, Ruth blames the mistake on Nadia. The soldier later dies after Adam and Maggie try to operate on him. It transpires that the superior is responsible for the shooting, after he was caught stealing and selling army equipment.

As Adam is telling the family that they could not save their son Toby bursts out laughing and is reprimanded by Adam and sent out on an observation with the paramedics. Davika is leaving for India much to Josh's disappointment as he really loves her. Meanwhile a family are walking through the woods when a car careers off the road through a field, runs down the mother and crushes the granddad into a tractor all the while with the young daughter staring on. It turns out that the driver was a drug mule and a package leaked into his stomach causing him to crash and subsequently die. The grandfather is in a very bad way and Toby tells him that he will probably die as the pressure of the tractor is keeping him alive, he later passes away and Toby faces his demons and tells the family while trying to keep his nerve. Ruth humiliates Adam as when he is trying to tell a woman her brother has died she wears a red nose trying to embarrass him, Adam asks why and she replies that if he doesn't take the blog down she will start acting like her nickname. Harry tries really hard to avoid Charlie or Tess being made redundant but is left with no choice but to let one of them go by Christmas. Josh decides that he will try and pursue this love life with Devika and jumps on the next plane to India.

After a late night out Toby and Kelsey are feeling the effects of their hangovers. A drug addict who is going to an appointment to sort her life out leaves her son, William, at his grandma's house. Unbeknownst to her, her ex-boyfriend, Steve, is in the grandmothers house trying to see their son. He is cooking meth when he accidentally knocks over the pan, blowing up the house. Harry offers Tess a transfer to outpatients and tells both her and Charlie that they have to find the blogger by the end of the day and terminate the site. They corner Adam in a room and tell him that they won't name him, he doesn't own up and tells them that he would never confuse them with 'they're', like the blogger has. Toby cheers Kelsey up with a bacon roll after she was kicked to the floor in cubicles. Adam drops Toby in about being the blogger as he is the only staff member that has been in every single day that the blog was written. He fully denies these claims. Tension rises between Charlie and Tess over who is going to be transferred. As William begins to crash the fire alarm in the department goes off causing an evacuation of the hospital. Steve gets aggressive and attacks Toby and then starts kicking off in resus and shouting at his ex and grandma. Tess, Charlie and Abs are forced to lock him in the other resus and barricade the door with a trolley while waiting for security. Greg has successfully got the post as a rapid response member.

With Ruth struggling to treat her patient she asks Adam to step in and with a little prompt she reaches the correct course of action. The patient is then stabbed by his brother in resus and dies from his new injuries. The police turn up and begin to interview all of the staff. Charlie turns up late for work after dropping Louis off at school. Harry tells him that he is not in a position to ask for favours after he asks for their meeting to be rescheduled. After smoking in the school store room, Louis and his friends accidentally set fire to the school. With resus closed because the police are examining the crime scene from earlier, Harry decides to upgrade HTC into the temporary resus. With the help of Big Mac, Toby manages to successfully unmask the true culprit behind toxicshark.com, T.C. Toby is forgiven of the false accusations and allowed to do proper doctoring duties instead of cleaning and laundry. After a gas canister explodes in the storeroom the teachers begin to evacuate. As they are trying to escape they are greeted by a fire door with a chain around it, forcing them to turn back to look for a different route out. Greg is first on the scene and despite Dixie's orders he enters the burning building, saving a whole classroom full of pupils. After hearing more screaming from inside the building, Greg ventures back in to find a girl impaled by a plank of wood. While treating her he begins to succumb to the smoke and he is then saved by the fire brigade. Charlie starts to think that the worst has happened to Louis after there has been no sighting of him leaving the building. Charlie finds out that Louis is safe as he skipped school after starting the fire, leaving every other pupil in the path of the impending fire. Adam calls Alice 'squeak' one too many times and she finally tells him her true feelings, about how he is being insensitive to both staff and patients. T.C. and Kelsey are put on punishment duties after Kelsey helps T.C. set up a prank to apologise for his recent blogging which causes Harry to have to lay down the law.

Charlie is still struggling to cope with Louis and while trying to ensure he doesn't skip school again he ends up missing yet another HR meeting. The board decides that the blog T.C. made was out of order and to terminate his contract within the department. Charlie gives him a second chance but revokes this after T.C. is caught selling goods on hospital premises. Meanwhile a GP is brought into the hospital after collapsing, Toby calls her partner without consent and the doctor is forced to tell him she is HIV +ve. As her partner goes to leave her son blocks him and punches him in the face, sharing blood, possibly infecting him. Toby's mum, Professor Windsor, visits the hospital for a lecture and to check up on Toby but witnesses him having a very bad day after a patient refuses to let him treat them. Louis gets expelled from school and Charlie goes to pick him up but he is not there. When he checks their house he finds a large bundle of money hidden in a shoebox. Tension rises between Dixie and Greg after Greg has to deal with a solo call to treat a security guard and no ambulance comes for over an hour. The patient later dies causing Greg to begin to lose faith in his job.

It's Tess' last day before she will be made redundant, while Charlie and Tess drop Louis off at a friends house they witness a woman being dragged under a car. Meanwhile an overweight woman comes into the hospital with stomach pains when it turns out that she has lost her baby. Toby realises that she may be cheating on her husband, Charlie tells him to tread carefully. After the woman phone's Charlie she tells him where she hid the baby, Charlie gets a lift from Dixie and Jeff and they find the baby, freezing cold. Jeff places the baby inside his top as Charlie says it's the best way to warm it up. As they make their way back Charlie gets out the ambulance after seeing Louis, who didn't turn up at his friends house, walking down the street. As he follows Louis he comes across the car from earlier that ran down the woman. The man then hits Charlie after the police give chase. The team give Tess a send off and they arrange a trip for her to go see her son, Sam. After Toby's patient, the woman with the baby, crashes he performs a solo cardiac shock. After Maggie congratulates him, he snogs Maggie under the mistletoe. Charlie suspects that something more may be going on between the two doctors. After Charlie tells the man who dragged the woman under the car that she died, Charlie punches the patient after he makes remarks about her, the patient retaliates injuring Charlie. Harry asks for Charlie's resignation, to which Charlie accepts in order to let Tess keep her job and to spend more time with Louis.

With the year drawing to an end Kelsey, Abs and Harry's daughter go to the Paradise club to end the year in style. Meanwhile a boy, Dean, with mental issues brandishes a gun in his mother while wearing his dads old army clothes. Meanwhile new doctor, Zoe Hannah's car runs out of petrol and she goes to a nearby farm house looking for fuel when she comes across the mother that has been shot. Meanwhile a girl that has been brought in after a car accident is clear of spinal injuries by Ruth, the girl later tries to stand up to go to the toilet but collapses and can not feel her legs. Meanwhile at the Paradise club Dean has managed to gain entry, looking for his target. As the nurses and Big Mac pop open a bottle of champagne at midnight, Tess storms in sending them all back to work. Kelsey and Abs, first on scene, give a young girl a tracheotomy with a straw much to Dixie and Jeff's praise. Abs follows Dean upstairs to try and treat him when he aims the gun at Abs. Back in the hospital, Ruth lies to Tess about what happened to the patient and blames what happened on Nadia and that she never said to discharge the patient or remove the collar.

After Abs suffers a gun shot wound after trying to calm down Dean, Tess begins to prepare the department for the impending rush of patients from the shooting. Marilyn is forced to scrub up and is given all of the gruesome task from Tess. Dean is shot by the police and is rushed into resus, where he crashes yet still dies even after she performs a tracheotomy. Tess treats Abs and tells him that the trust can not be held responsible and will not let Abs help out. He disregards Tess' orders and gets Dean's mum to open up and to tell the police that it was Dean who shot her. Adam's patients waters break just as he is about to leave for a party. Adam and Alice then begin to take her up to the ward when the elevator breaks. After receiving a call from his girlfriend asking where he is, the sound of the woman in labour makes her think that Adam is cheating on her and she breaks up with him. The pair are forced to deliver the baby in the lift. Adam's claustrophobia begins to worsen forcing Alice to take the lead in helping to birth the baby. Tess warns Ruth and Nadia that one of them is lying and that she wants the truth by the end of the day or there will be a formal investigation of how the patient was injured in the hospital. With Harry's daughter still missing after the shooting, he snaps at Marilyn after she complains about missing pudding even with all of the injured patients who are also not here by choice. When Harry's daughter turns up, it transpires that Dean has hid his younger daughter in the car after he could not bring himself to kill her. Nadia decides to take full responsibility and hands in her resignation to Tess.

New receptionist Noel he is quick at pulling pranks and joking with colleagues. A young hitchhiker, Joe, catches a lift from a lorry driver, after she brandishes a screwdriver on him they swerve off the road into a caravan. Abs calls for a nurse meeting after receiving a letter from the nurses union about Charlie's situation, the union decide not to support them and Abs decides that the nurses will do an unofficial work-to-rule where the nurses will do the bare minimum as stated in their contract. Ruth goes out to the accident scene as the response doctor after a prolonged entrapment. Ruth makes another careless mistake after not checking how much morphine Greg gave Claire before giving her more causing a morphine overdose. Ruth then begins to insinuate to the boyfriend that she knows that he is beating Claire and locking her in the caravan but it turns out that it is her that is neglecting him. Marilyn threatens Kelsey that if this work-to-rule continues then another nurse might lose their job. After the driver of the lorry dies Zoe blames Abs for his death, Abs then makes an inspirational speech about how he is not the issue and how hard nurses work and that they go above and beyond their job description yet when they do what they're paid to do they are blamed for negligence.

In a chocolate factory a man has fallen into a chocolate vat. Dixie jumps in to rescue him after he starts to drown, she then gets stuck and begins to sink with the patient but is rescued by the fire brigade. Meanwhile a woman's leg is amputated when a train runs over it and is brought into resus. New nurse Lewis is straight into resus but Tess quickly sends him out due to his lack of experience. Kelsey and Alice set up dating sites after Adam suggests it to them. The patient from the chocolate factory stops breathing for no reason while being treated by Lewis and is rushed into resus where Harry praises Lewis for his quick response. It turns out that the woman wanted the train to amputate her leg so Zoe diagnosed her with BIID (Body Integrity Identity Disorder, desire for elective impairment). After Maggie interferes with Zoe's patient, Zoe makes it clear to Maggie that she won't tolerate it. Her patient then begins to spasm while Lewis takes her up to theatre. Tess shares her suspicions about Lewis to Abs. While Tess is taking a patient's body to the morgue she is ambushed by Lewis who injects her with the same substance he gave to the other patients. Big Mac finds her and races her into resus. The team begin to treat her and as she begins to regain consciousness she warns the team that it was Lewis and they seal off the hospital. Big Mac successfully manages to apprehend him. Lewis says that he did what he did, so that he could then save their lives in resus and impress other people. After the shift Adam goes out to an engagement party where he meets Jessica Harrison and they have a one night stand together.

Maggie's daughter begins her contractions, Jeff is injured in a pub brawl making Greg consider whether he should resign after Dixie calls him a liability. While vandalising the underside of a bridge, the man slips and is left dangling down from the bridge. Greg is first on the scene. The rope snaps and he falls onto the road causing a car pile up. As Greg checks out the damage he finds that his patient from last week, Ruby, was involved in the crash. Chloe, the mother, has been impaled through the stomach and is trapped in the car. A chemical from a van begins to spread across the scene causing the fire brigade to tell the paramedics to retreat. Chloe passes away and Greg tells Ruby that her mother is just sleeping. Back in the hospital Ruth is treating the graffiti artist in cubicles while Adam treats Ruby, After Adam requests a blood gas for Ruby, Kelsey tells him that seen as she is on an agency shift she can not do them much to Adams disgust. Kelsey asks Adam to step outside where she tells him that she is not impressed with his attitude. Tess is forced to close the department as they can not cope with all the patients, even though Dixie and Jeff are literally minutes away they are forced to divert to St James, an extra 10 minutes away. It then transpires that the chemical was Carbon tetrachloride, Ruby dies after Adam, Kelsey and Zoe try desperately to resuscitate her for 30 minutes. Tess shouts at Abs blaming the work-to-rule in causing the death of the elderly man ,that Dixie had in the ambulance, and Ruby. The department gather outside to see themselves in graffiti as the graffiti artist from earlier made them a tribute.

Following Ruth's suicide attempt, Harry reads through her diary as the events of the past few months are revealed through the use of flashbacks. It begins with her arrival to the hospital and then about her family. It then shows that Adam set Ruth up to shadow the histology department much to Ruth's annoyance but she decided to stay there. Ruth's histology friend, Dominic, manages to secure her a slot in assisting Sarah Evans in surgery on Boxing Day. She then feels led on by Dominic which in turn adds to her depression when he turns her away. Ruth's suicide letter states that her life is summed up by 3 pieces of paper: a birthday card from a father that never loved her, a Christmas card from a man she thought did and a visiting order from her brother. After the incident the team go to the pub to drown their sorrows where Maggie feels bad after Ruth previously asked her for guidance to which she refused to help. Adam and Zoe share a kiss outside the pub where they decide that they are not compatible and to forgot about the incident. Adam then continues to flirt with Jessica and offers to walk her home. Harry tells Tess that the department has let Ruth down by not being there for her.

Toby calls off work sick and Harry is desperate to see him to check on how he is coping after Ruth's suicide attempt. He does not want the department to fail Toby as well as Ruth. Everyone is directed to Holby after St James deals with a major RTA. Meanwhile a group of 3 kids run through the woods after overdosing on antidepressant pills. After bumping into an estranged old man the boy ends up stabbing the man in the stomach. Marilyn tries to force Harry to sign off on a press report that says that Ruth could not cope and that it was her own fault. While attending the call to the woods, Dixie, Jeff and Snezana manage to get the ambulance stuck in the mud. Meanwhile at the pub Toby is forced to help deliver Maggie's daughters baby while he is under the influence of alcohol. Dixie and Jeff do not notice the girl in the woods and leave to assist Toby, presuming the call is a hoax, only to find the stabbed man in the middle of the road. Johanne's baby's cord is stuck and Toby calls Tess to try to get help as the ambulance has been delayed. When the paramedics arrive Snezana argues with Dixie over whether they should risk delivering the baby in the pub or attempt to transport her to the hospital. Toby is given the final decision and chooses to deliver the baby in the pub. The young girl who was in the woods with the boys collapses and is found by police and brought in. Adam, Harry and Kelsey treat her when she begins to deteriorate. They then discover that her friend was the one who stabbed the elderly man with dementia who is fighting for his life in resus. Harry refuses to let Maggie have a few hours off to see her daughter in maternity. Harry then gives Toby a week off for compassionate leave if he agrees to see a specialist. Marilyn threatens him that if he goes public with Ruth's diary then the board will ensure that he loses his job.

Toby returns after his compassionate leave and tells Harry that he thought that him of all people would have supported Ruth after reading the newspaper article. Curtis and Jeff bring in a patient with a severe leg injury, Sean Anderson comes down to the department to assist Toby and Zoe in treating the patient. Dixie and Snezana bring in a young girl who has been impaled in the neck by a bracket, Harry tells Toby that the two of them will work together on the case. Toby manages to form a connection with the patient and successfully manages to treat her, Harry treats the mother and discovers that she has been burned by an iron on her back, she confides in Harry over how her husband has been beating her. After Toby's patient begins to deteriorate Tess suggest paging Harry, Toby then puts Martha to sleep in order to intubate her, when he can't fit the tube down her throat he is forced to perform a surgical airway, Adam tries to stop him as he has not been trained but Harry decides to let him try and encourages him. After he successfully manages the airway, he is praised by the team. Adam criticises Harry over leaving Toby by himself when Harry tells him that him flirting with Jessica wasn't exactly productive either, Adam then tells him that he had already offered his services earlier to which Harry refused. Noel breaks patient confidentiality after telling the woman's abusive partner that she is in cubicles. It then transpires that the husband is not only abusing the mother but also the daughter. A formal complaint is lodged against Jeff after he makes offensive and racist remarks towards a patient. Harry reaches out to the press and gives them Ruth's diary as he believes it will help hundreds of F2's like her.

With Ruth now off life support, she is beginning to recover but is still not awake, Adam braces the team that they will make one final attempt to take Ruth off of sedation and warns them that they should say their farewells. Harry is brandished by the press as part of the cover up, Marilyn tries to make a scapegoat out of Harry after the public cry for the boards resignation. The team applaud Harry for his actions when he then tells them that this will be his last day as consultant manager of the department. Meanwhile a construction worker falls from his site and is rendered unconscious, during his fall his building materials also land on other workers and on a car. Adam and Harry clash while treating the man who fell and argue over whether to intubate or not, their argument spills out of resus and into the corridors where Adam questions him as to why he waited so long to release the diary. Charlie is working in a Health Centre where he is treating a patient with whiplash. Marilyn makes an official press conference criticising Harry's actions, he then suggests to Adam that he should become the next Clinical lead which Adam declines. After Harry's departure, Toby finally manages to pluck up the courage to visit Ruth when after speaking to her, she begins to move. Harry decides to play one last ace-By inviting Charlie to return to the ED.

Jessica and Sean take their children to school; they are still keeping their marriage secret from the rest of the staff, while Sean is continuing to see Zoe. Ruth returns to clinical duties and helps out with a stabbing victim but backs away from assisting with a diabetic. A young teenage boy, Daz, hangs around outside a house until chased away by the owner and later has a panic attack on a bus and jumps out of the emergency exit window in front of a car. He seems to have traumatic amnesia and, when he turns out to be allergic to latex, Sean remembers him as the only survivor of a multi-car pile-up in which his parents and sister were killed, which he has repressed; he now lives with his uncle Terry. Zoe bluntly tells him of his parents' death and Terry and Snezana help him through his renewed grief. Snezana later looks at a photo of a little girl. Abs' friend Stacey is fired from work after being accused of being drunk and proceeds to get drunk at home and burn his arm cooking. His girlfriend Ellie takes him into work but he refuses Abs' offer of help, crashing his car while trying to leave. Ruth, unaware of the full situation, allows him to discharge himself. With help from Alice, Adam arranges a romantic meal in the car park with Jessica. They kiss but she dashes off, saying it can't work.

Ruth deals with Gordon, who has dislocated his shoulder, but is unable to relocate it and has to call Toby for help. Curtis and Snezana are called out to an estate where a young man, Ben, has been stabbed. Curtis manages to hide the fact he knows Ben from his time with a gang. A young man, Kay, and his mother Hasina learn their house has been put up for sale. Husband and father Khalid has lost his job and is secretly working as a taxi driver but Kay thinks he is having an affair and tries to burn his things. Hasina accidentally causes an explosion by throwing the petrol can onto the fire and is badly burned. Ruth convinces Charlie and Maggie to let her talk to Khalid before she is intubated but she later dies in Resus. Alice goes on a date with internet partner Bruce and kisses him but is reluctant to invite him in. She finds her mother Julie attending to a gentleman caller and texts Bruce saying they shouldn't meet again. Joanne kisses Toby. Ruth returns home with some pills.

Ruth is seemingly writing a suicide note but is interrupted by Maggie and goes out for a run. Parents Mike and Gill pick up their daughter Rose, who has Down's syndrome, from a care centre and learn she is dating one of the other attendees, David, who gives her a letter. Mike and Rose argue in the street and Rose collides with Ruth, who stops her being hit by a motorcyclist who instead hits Gill. Ruth accompanies the group to hospital. A priest, Father Murray, flirts with a cleaner, Christine, who badly cuts her hand. Adam and Toby argue over treating Gill, who Sean realises has a dislocated pelvis. Adam and Zoe realise Sean and Jessica are married when she retrieves his watch. Mike tries to stop David seeing Rose and he reveals he was proposing to her in the letter. Ruth realises a wire from a heart operation Rose had has come loose and she needs surgery urgently but she refuses unless she can get married first. Mike convinces Murray to perform a blessing. Christine feels she has tempted Mike but he refuses to lie anymore and says he loves her. Ruth babysits Joanne's daughter Lana and throws her pills away.

Maggie is unaware that Toby and Joanne are sleeping together. Charlie gives Louis a lift to a concert. Along the way, they stop to help Annie, a woman who has broken down; Charlie is oblivious to the fact she is the singer from the concert and she is impressed when he helps a service station worker having an asthma attack. Ellie lets Stacey look after their son Joey but he takes him to a park and gets drunk. Joey pricks himself on a discarded syringe and Stacey attacks Joey's teacher Alan thinking he is abducting him. Ellie refuses to let Stacey back into the house until he sobers up. Lucy, a woman who came in with stomach pains, is discovered to be pregnant but insists she hasn't had sex since her husband left her over a year ago. Her lodger Justin, who has a scarred face from saving a colleague's life in Afghanistan, admits they had sex while she was drunk and she doesn't remember. He plans to make a statement to the police but she probably won't press charges. A couple, Jonathan and Julie, offer to have sex in front of first Justin and then Curtis and Snezana with Jonathan ending up banging his head; they admit it was a half-hearted attempt to spice up their marriage. Abs encourages Ruth to connect with patients. She accuses an elderly woman, Mrs McFarlane, of being a time waster but later buys her a magazine.

A sex worker, Cindy, is waiting for a client in a hotel room but loses her nerve and falls while trying to climb out a window. She asks the hospital staff to call her boyfriend Liam. Another woman, Miranda, goes to the hospital asking to be sectioned, saying she's been heartbroken since her husband left. She deliberately drives into a car containing engaged couple Eddie and Flora, who were on their way to Las Vegas. Flora dies in Resus and Eddie takes an insulin overdose but the staff revive him. Liam turns out to be Miranda's husband. On learning Cindy took work as a prostitute to try and get them a flat, he asks Miranda to take him back but instead she turns herself in to the police. A young man, Lol, comes in with a head injury. His girlfriend Sally insists he is possessed, since his accent changed after a blow to the head. Ruths and Abs realise he has foreign accent syndrome and Sally hit him to try and change him back, managing to reconcile the couple. Charlie is unhappy about Zoe and Marilyn's plans to open up a private clinic for minor injuries in the department. Toby loses his sthethoscope, which Snezana has. Adam and Jessica decide to keep their distance, then promptly kiss.

Charlie clashes with Simon Tanner, the nurse in charge of the Minor Injuries Unit. Brothers Gary and Bob perform their wire act at a superhero convention, with Bob dressed as a superhero, but Gary drops him, although his harness saves him from serious injury. Charlie is treating him for broken ribs when Simon convinces him to use the minor injuries clinic. As a result of Noel giving him the wrong notes, Simon gives Bob medication he is allergic to. Adam discovers he actually has a ruptured spleen and he is sent for surgery. Charlie notices Gary has a tremor in his hand and suspects he has MS, but Gary refuses to look into it since the act is his and Bob's life. Ruth helps Noel reorganise the filing system to better cope with the two sets of patients. Tom, an author at the convention, is pleased that George, a fan who won a competition to meet him, is an attractive blonde woman and invites her for dinner. His assistant Sarah collapses from a peanut allergy but he refuse to accompany her to hospital. Jessica realises she deliberately caused an allergic reaction to get his attention. George visits her with flowers which she claims are from Tom but Sarah realises are from her. Sarah refuses to see Tom. Kelsey continues to message "James", unaware it is Mac.

Guest starring Mark Little as Gary Forrester, Martin Crewes as Gary Forrester and Kazia Pelka as Sarah Brown

A young man, Ian, finds his brother Steve hiding in the shed, having apparently been attacked by a vigilante mob. He has given a young girl, Beth, a broken arm by hitting her with his car so Ian takes her to hospital. The police are suspicious since Steve is facing charges for abducting a minor. Ian tells Charlie that Steve took a girl to the park without oermission and will probably end up in a mental hospital. Beth shows signs of carbon monoxide poisoning and says her nana wouldn't wake up. Maggie takes Dixie and Ian to check out her house and finds an old man and dog dead and an elderly woman in a bad way because of a leak. Zoe arranges for Maggie and Ruth to take a course. Mac messages Kelsey as James saying he'll be back in the country soon. An elderly woman, Mrs Stirling, has a leg injury but insists she also has back cancer. Simon refers her to a private clinic for a full body sca and Charlie realises the Minor Injuries Unit receives payments for referring patients. Arjan, an older man who had a fall, wants to see a doctor. He is convinced to use the MIU but, since he refuses to go private, Simon can only look him over and then send him to the back of the queue in reception. Marilyn gives Adam a bonus to look him over and arranges a pay rise for Noel to cover both units.

Sheila, an elderly woman with Alzheimer's, wanders into the garden of her obnoxious neighbour Terry where he is throwing a party with his son Tel and heavily pregnant teenager Amber, who turns out to be Terry's girlfriend. Terry and Amber torment her and her husband Howard starts a fight in which Terry is pushed through broken glass, Amber is badly burned after falling on a barbecue and scaffolding falls down on Howard. Amber goes into labour and gives birth to a baby girl. Terry tries to stop the hospital staff finding her notes but a social worker, Lissa, reveals Terry is a serial sex offender and the baby has to be taken into care. Maggie tries to convince Amber to look after the baby on her own but Amber headbutts her and lets the baby be taken away, choosing to stay with Terry, who she says saved her from an abusive stepfather. Jeff and Snezana find Sheila and bring her to hospital. Howard admits to Abs that he was going to leave her until she was diagnosed. He suffers a stroke that leaves him debilitated; Sheila will have to be placed in elderly care. Jeff and Dixie suspect Snezana has been stealing from the ED. Stacey turns up and Abs tries to get him into rehab. Curtis finds him collapsed in the street but he disappears before Zoe can run tests. Marilyn offers to set up an alcohol unit if Abs withdraws his opposition to the MIU, which he does. Alice finds out Mac is James but is unable to tell Kelsey. Toby invites Maggie out for dinner as a thank you but she arrives home to find him in bed with Joanne.

Jeff and Snezana find a drug addict collapsed from an overdose, who is declared dead in hospital. Jeff suspect Snezana is a drug addict and Curtis gets her blood tested in secret but it comes back clear. Joanne tells Toby that Maggie fancies him and he decides they should move out. A heavily pregnant woman, Jo, sees a young man, Kris, following her around a shopping mall. He later tries to get into her car, causing her to run over Maxine, a woman confined to a wheelchair by rheumatoid arthritis, who had been arguing with her daughter Sally over the fact Sally had been in contact with her father. Maxine is cruel towards Sally at hospital and is later rushed to theatre with internal bleeding from overdosing on a medication cocktail. Kelsey realises Kris is the son Jo gave up for adoption twenty years ago, which Jo has to tell her husband Andrew about. Simon insists Maggie check on Kris' leg pains. She suspects DVT and orders tests to confirm it but Simon lets him walk out. He collapses outside and dies in Resus from a pulmonary embolism. The notes have been lost by Noel's new filing system and Simon produces fake ones saying Maggie dismissed it as a tendon injury. Charlie vows not to let Maggie be made a scapegoat. Mac and Alicia have sent Kelsey an e-mail saying James has been killed. It is only after comforting Jo that she admits she is grieving.

Stacey is having hallucinations from alcohol withdrawal. A father, Rizwan, is trying to leave for the airport with his teenage daughter Nazrin before his wife Trish gets home and pulls out in front of Stacey, causing a crash. Abs assumes Stacey has been drinking but Ruth realises what's really going on and the breath test comes back clear. Ellie, however, leaves without finding this out. Zoe tells Maggie there will be a coroner's inquest into Kris and she will be supervised until then. Maggie discovers evidence that Nazrin has been beaten and it transpires Trish was responsible. Toby is looking at flats for himself, Joanne and Lana. Maggie and Toby argue over Nigel, a patient with a hand injury. Nigel reveals he is an estate agent and Toby gives him money for a property but Joanne disappears, leaving a note for Toby. He then learns Nigel has conned him. Kelsey plans to go to James' funeral.

Toby has been sleeping in the on-call room since breaking up with Joanne. He latches onto Holly, a single mother he knew from medical school who came in with a broken ankle. Sean asks him to finish off the operation but he fails to align the pins properly, putting her at risk of being crippled. Ben and Briony, siblings with eating disorders and a co-dependant relationship, come in after Ben has fallen down some stairs. Ben turns out to have been taking laxatives and Adam lies to Briony that he's died to try and shock her into accepting they need help. Ben has heart problems and ends up comatose in ICU but Briony carries on purging. Adam looks after Amelia and Lucas when Sean leaves them with Jessica during a shift. Zoe sees them together and renews her affair with Sean. Kelsey and Mac spend time together helping an English teacher with terminal cancer. Kelsey goes to a funeral at the time she was told but it isn't James'. Mac admits the truth and Kelsey realises Alice knew, having a go at her in front of their friends at a party before copping off with a stranger.

Sean and Jessica are having liaisons with Zoe and Adam respectively and miss a call from the childminder saying she can't pick up Lucas from school. Lucas walks off with a Serbian girl, Natasa, and is hit on a pelican crossing by a car which ignored a red light. The driver, Joseph, tells the police Lucas ran out when the light was green and pressures his daughter Rachel to back him up. Snezana shields Natasa from the police; Jeff realises Natasa and her father Marko are illegal immigrants and Snezana provided her with a stolen inhaler. Lucas is found to have a brain injury. Rachel tells Charlie her mother died of breast cancer and he convinces Joseph to tell the truth. Jessica prays for Lucas to recover, promising to give up Adam. Tess assigns Kelsey and Alice to work together on Ireland, a compulsive gambler who got beaten up after winning someone's BMW. It transpires he failed to follow up on a cancer appointment and is now terminal. Alice manages to get Kelsey and Mac in the same room. Simon is interviewed by the coroner and Charlie is caught trying to get evidence from Marilyn's computer. Simon tells Marilyn the truth and she decides not to punish Charlie in the hope of keeping him on side.

Marilyn discovers Zoe and Sean's affair and blackmails Zoe, wanting her to lie to the coroner's court that she heard Maggie give Simon the wrong instructions. Jessica is holding vigil over a recovering Lucas; Adam tells her he loves her but she says she doesn't feel the same way. Branka, a Kosovan immigrant, is working as a cleaner at a nursing home. She finds an air gun in her son Goran's bag and, during a struggle, Branka is shot in the face and Josie, a patient who has been in a coma for four years, is knocked out of bed. Josie is taken to hospital where her estranged parents Val and Tony turn up; Tony has a pregnant girlfriend, Hannah, and hasn't visited Josie in a year. Josie is found to have a bleed on the brain and Val and Tony sit with her as she dies. Jeff follows Snezana to a farm and finds her treating immigrants, including giving drugs and injections she isn't qualified for. Branka finds Goran is selling air guns to the other children and collapses, bleeding. She is rushed to hospital where it turns out the bleeding was the result of being wrongly prescribed warfarin. Branka decides she and Goran will go back to Kosovo. Snezana tells Jeff she has a twelve-year-old daughter, Maya, who lives with her grandmother and Jeff agrees to keep quiet if she stops. Toby sees Holly in a wheelchair in reception.

A boy, Ben, leaves his younger sister Grace alone in the house while he tries to steal from a supermarket. He is spotted by a security guard and injured jumping off a building. The hospital staff realise he is deaf and Mac communicate with sign language, learning about Grace. It transpires their mother has disappeared and Grace is taken to a children's home. Luke's mother arranges for a journalist to shadow him as a promising young doctor but he points the man towards Ruth when he sees Holly in reception. Marko and several other immigrants are working at a quarry where the boss, Greyling, molests Mina, the wife of worker Milosch, in his office. Marko asks Snezana for another inhaler but she tells him he'll have to go to hospital. He collapses while driving a truck and crashes into a pile of debris. Jeff and Snezana climb into the unsafe cab to treat him. Simon continues to lie in the coroner's court and blame everything on Maggie, who is blasted by Kris' mother Pam. Charlie asks Zoe, Noel and Ruth to look for the missing notes. Jessica finds them and gives them to Zoe.

Maggie is cleared at the coroners court as Zoe tells the truth about Simon's duplicate notes about the patient who Maggie was accused of killing. Maggie later decides to leave the Emergency Department, asking Charlie to come with her to travel. He declines and says he has a son to look after but it is the best invitation he has ever had. Elsewhere the paramedics are caught in a landslide at a quarry where illegal Kosovan immigrants have been working. One worker, a friend of Snezana, dies, and Maggie promises Snezana she will take the worker's daughter back to her family in Serbia. Toby and Ruth have a heart-to-heart and Ruth tells Toby to admit the medical mistake he has made to Sean. Abs is caught kissing his friend Stacey's wife. The court case is taken to the police. As the episode closes, Maggie and Charlie share a kiss.