Caylus may refer to:
People
- Anne Claude de Caylus (1692–1765), French archaeologist
- Charles de Tubières de Caylus (1698–1750), French naval officer, governor of Martinique
- Claude Abraham de Tubières de Grimoard de Pestel de Lévis, duc de Caylus (c. 1672–1759), French military leader
- Marquise de Caylus (1673–1729), French noblewoman and writer
Places
- Caylus, Tarn-et-Garonne, France
Other
- Caylus (game), 2005 board game by William Attia
- House of Rougé, holding the duchy of Caylus and the title Duke of Caylus
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