Chalis or chalisa may refer to:
- The number forty in some South Asian languages including Hindi-Urdu
- The Chalisa famine that hit South Asia in 1783, which is 1840 in the Vikram Samvat calendar
- A Hindu hymn (stotra) of forty verses
- Stefanos Chalis (1796–1821), a chieftain in the Greek War of Independence
See also
- Challis (disambiguation)
- Chalise, a surname
- Chalice, a cup used in ceremonies such as the Eucharist
- Chali, a Germanic tribe mentioned by Ptolemy
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