Chamberlayne is a surname. Notable people with the surname include:
- Edward Chamberlayne (1616–1703), English writer
- Francis Chamberlayne (after 1667–1728), English politician
- George Chamberlayne (c. 1703–1757), British politician
- John Chamberlayne (c.1668–1723), English writer, translator, and courtier
- Tankerville Chamberlayne (1840–1924), English Member of Parliament
- Thomas Chamberlayne (disambiguation) several men with this name
- William Chamberlayne (poet) (1619–1679), English poet
- William Chamberlayne (MP) (1760–1829), English Member of Parliament and landowner
- The Chamberlayne family, an influential family of Weston, Southampton, United Kingdom
- The Chamberlayne family, an influential family in Virginia, descended from William Chamberlayne (burgess) of Hereford who settled in New Kent County, Colony of Virginia
If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link. Categories: