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Charles Joseph Epstein (September 3, 1933 – February 15, 2011) was an American geneticist who was severely injured in 1993 when he became a victim of a mail bomb attack by the Unabomber. He was a researcher at the University of California, San Francisco and the Buck Institute for Age Research.

Education

He was first in his 1959 class at Harvard Medical School, and then interned at Harvard's Peter Bent Brigham Hospital.

Career

Epstein began his work in medical genetics—the application of genetics research to human care—in a fellowship with Arno Motulsky, one of the founders of medical genetics, at his Seattle University of Washington lab. While there, Epstein worked to understand the nature of Werner's syndrome, a genetic disease that causes premature aging.

He is most notable for conducting groundbreaking research on Down syndrome. In 1967 he became the chairman of the medical genetics division in the pediatrics department of UC San Francisco. He did research on making a mouse model for Down syndrome.

Epstein was the president of the American Society of Human Genetics in 1996 and the editor-in-chief of the American Journal of Human Genetics from 1986 to 1993. (He became the official editor-in-chief on the 1st of July 1986 and was severely injured in June 1993.)

During the last 10 years of his life, Epstein participated in the formation of the Buck Institute located in Novato, California, serving as chairman of its scientific advisory board and board of trustees.

Unabomber

In June 1993, Epstein received a mail bomb sent by Ted Kaczynski, known at the time as the Unabomber. The explosion severed several of Epstein's fingers, caused abdominal injuries, and resulted in a partial loss of his hearing.

Death

Epstein died on February 15, 2011, at the age of 77 after a protracted struggle with pancreatic cancer.

Works

• Search Results for author Epstein CJ on PubMed.

References

1. ^ Fagan, Kevin (2011-02-20). "Dr. Charles Epstein, Down syndrome pioneer, dies". SFGate. Retrieved 2016-04-21.
2. ^ Fox, Margalit (24 February 2011). "Charles Epstein, Leading Medical Geneticist Injured by Unabomber, Dies at 77". The New York Times. Retrieved 2016-04-21.
3. "North Bay survivor of Unabomber attack dies at 77 – San Jose Mercury News". Mercurynews.com. 17 February 2011. Retrieved 2016-04-21.
4. "Buck Institute Mourns Death of Former Board Chair Charles J. Epstein, MD". BUCK. Retrieved 2023-06-13.
5. "UW Genome Sciences: Arno Motulsky". Gs.washington.edu. Retrieved 2016-04-21.
6. Epstein CJ, Graham CB, Hodgkin WE, Hecht F, Motulsky AG (1968). "Hereditary dysplasia of bone with kyphoscoliosis, contractures, and abnormally shaped ears". The Journal of Pediatrics. 73 (3): 379–86. doi:10.1016/s0022-3476(68)80115-5. PMID 5667420.
7. Epstein CJ (June 2006). "Down's syndrome: critical genes in a critical region". Nature. 441 (7093): 582–83. Bibcode:2006Natur.441..582E. doi:10.1038/441582a. PMID 16738647. S2CID 5577410.
8. Wynshaw-Boris, Anthony; Risch, Neil; Motulsky, Arno (2011). "Charles Joseph Epstein, M.D., 1933–2011, In Memoriam". The American Journal of Human Genetics. 88 (6): 684–688. doi:10.1016/j.ajhg.2011.05.016. ISSN 0002-9297. PMC 3113342. PMID 21805720. (This obituary contains a typographical error: "seven years (1987–1993)" should be replaced by "seven years (1986–1993)".)
9. Cannizzaro, L. A.; Emanuel, B. S.; Cho, K. W.; Weinmann, R. (1986). "The gene encoding the large subunit of human RNA polymerase II is located on the short arm of chromosome 17". American Journal of Human Genetics. 38 (6): 812–818. PMC 1684854. PMID 3460332. (See the New Editor notice on page 818.)
10. "Charles Epstein Obituary - San Francisco, CA | San Francisco Chronicle". Legacy.com. Retrieved 2016-04-21.

• 1933 births
• 2011 deaths
• American geneticists
• Medical geneticists
• University of California, San Francisco faculty
• Harvard Medical School alumni
• Scientists from Philadelphia
• Unabomber targets
• Deaths from pancreatic cancer in California
• People from Tiburon, California
• Harvard College alumni
• American amputees
• American Journal of Human Genetics editors
• Members of the National Academy of Medicine
• American scientists with disabilities
• 20th-century American biologists