Charles Sawyer may refer to:
- Charles E. Sawyer (1860–1924), personal physician to President Warren G. Harding
- Charles Henry Sawyer (photographer) (1868–1954), American painter and photographer
- Charles H. Sawyer (politician) (1840–1908), governor of New Hampshire
- Charles H. Sawyer (neuroendocrinologist) (1915–2006), American neuroendocrinologist
- Charles J. Sawyer (1876–1931), London bookseller
- Charles Manville Sawyer (1876–1950), first governor (president) of the Federal Reserve Bank of Kansas City
- Charles Sawyer (sportsman) (1856–1921), English cricketer and rugby union footballer
- Charles W. Sawyer (pilot), American World War II fighter ace
- Charles W. Sawyer (1887–1979), Secretary of Commerce during the administration of President Harry S. Truman; U.S. ambassador to Belgium and Luxembourg
- Charles B. Sawyer, inventor of the commercial quartz crystal manufacturing process
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