Charles Shepard may refer to:
- Charles Biddle Shepard (1808–1843), Congressional Representative from North Carolina
- Charles C. Shepard (1914–1985), American microbiologist
- Charles Upham Shepard (1804–1886), American mineralogist and chemist
- Charles E. Shepard (1868-1932), American architect based in Kansas City with initials C.E.S., including for design of Charles S. Keith House.
See also
- Clarence Erasmus Shepard (1869-1949), also an American architect based in Kansas City with initials C.E.S.
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