Cherenkov luminescence imaging (CLI) is an emerging imaging modality, similar to bioluminescence imaging, that captures visible photons emitted by Cherenkov radiation. It basically is the optical imaging of radiotracers that emit charged particles traveling faster than the phase velocity of light in that particular medium. It can be used to quickly evaluate radio tracers in preclinical research but also to obtain clinical images in patients. While radioactivity itself can not be modified, the emitted light provides an opportunity to generate radioactivity-based activatable or "smart" imaging agents that sense for example enzymatic activity.
References
- Ciarrocchi, Esther; Belcari, Nicola (2017). "Cerenkov luminescence imaging: physics principles and potential applications in biomedical sciences". EJNMMI Physics. 4 (1): 14. doi:10.1186/s40658-017-0181-8. ISSN 2197-7364. PMC 5346099. PMID 28283990.
- Ruggiero, A; Holland, J. P.; Lewis, J. S.; Grimm, J (2010). "Cerenkov luminescence imaging of medical isotopes". Journal of Nuclear Medicine. 51 (7): 1123–1130. doi:10.2967/jnumed.110.076521. PMC 3068779. PMID 20554722.
- Zhong, J.; Qin, C.; Yang, X.; Zhu, S.; Zhang, X.; Tian, J (2011). "Cerenkov luminescence tomography for in vivo radiopharmaceutical imaging". International Journal of Biomedical Imaging. 2011 (641618): 1–6. doi:10.1155/2011/641618. PMC 3124671. PMID 21747821.
- Desvaux, E.; Courteau, A.; Bellaye, PS.; Guillemin, M.; Drouet, C.; Walker, P.; Collin, B.; Decreau, R. A. (2018). "Cherenkov luminescence imaging is a fast and relevant preclinical tool to assess tumour hypoxia in vivo". EJNMMI Research. 8 (1): 1–6. doi:10.1186/s13550-018-0464-7. PMC 6301908. PMID 30574662.
- Thorek, D. L.; Riedl, C. C.; Grimm, J (2013). "Clinical Cerenkov Luminescence Imaging of 18F-FDG". Journal of Nuclear Medicine. 55 (1): 95–98. doi:10.2967/jnumed.113.127266. PMC 3903390. PMID 24078721.
- Thorek, Daniel L J; Ogirala, Anuja; Beattie, Bradley J; Grimm, Jan (2013). "Quantitative imaging of disease signatures through radioactive decay signal conversion". Nature Medicine. 19 (10): 1345–50. doi:10.1038/nm.3323. PMC 3795968. PMID 24013701.
- Mitchell, G. S.; Gill, R. K.; Boucher, D. L.; Cherry, S. R. (2011). "In vivo Cerenkov luminescence imaging: a new tool for molecular imaging". Philosophical Transactions of the Royal Society A. 369 (1955): 4605–4619. Bibcode:2011RSPTA.369.4605M. doi:10.1098/rsta.2011.0271. PMC 3263789. PMID 22006909.
External links
- "A new nuclear imaging prototype detects tumors' faint glow". Science News. 2022-04-18.
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