Misplaced Pages

Chitinase A N-terminal domain

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
(Redirected from Chitinase A) Protein family
ChitinaseA_N
crystal structure of chitinase a from s. marcescens at 1.55 angstroms
Identifiers
SymbolChitinaseA_N
PfamPF08329
Pfam clanCL0159
InterProIPR013540
SCOP21ctn / SCOPe / SUPFAM
CDDcd02848
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In molecular biology, the chitinase A N-terminal domain is found at the N-terminus of a number of bacterial chitinases and similar viral proteins. It is organised into a fibronectin III module domain-like fold, comprising only beta strands. Its function is not known, but it may be involved in interaction with the enzyme substrate, chitin. It is separated by a hinge region from the catalytic domain; this hinge region is probably mobile, allowing the N-terminal domain to have different relative positions in solution.

References

  1. ^ Perrakis A, Tews I, Dauter Z, Oppenheim AB, Chet I, Wilson KS, Vorgias CE (December 1994). "Crystal structure of a bacterial chitinase at 2.3 A resolution". Structure. 2 (12): 1169–80. doi:10.1016/s0969-2126(94)00119-7. PMID 7704527.
  2. Perrakis A, Ouzounis C, Wilson KS (1997). "Evolution of immunoglobulin-like modules in chitinases: their structural flexibility and functional implications". Fold Des. 2 (5): 291–4. doi:10.1016/s1359-0278(97)00040-0. PMID 9377712.
This article incorporates text from the public domain Pfam and InterPro: IPR013540 Category: