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Cholestanetetraol 26-dehydrogenase

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Enzyme
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cholestanetetraol 26-dehydrogenase
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EC no.1.1.1.161
CAS no.62213-60-9
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In enzymology, a cholestanetetraol 26-dehydrogenase (EC 1.1.1.161) is an enzyme that catalyzes the chemical reaction

(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + NAD {\displaystyle \rightleftharpoons } (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + NADH + H

Thus, the two substrates of this enzyme are (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol and NAD, whereas its 3 products are (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al, NADH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD 26-oxidoreductase. Other names in common use include cholestanetetraol 26-dehydrogenase, 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase, TEHC-NAD oxidoreductase, 5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD, and 26-oxidoreductase. This enzyme participates in bile acid biosynthesis.

References

  • Masui T, Herman R, Staple E (1966). "The oxidation of 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha, 26-tetraol to 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol-26-oic acid via 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol-26-al by rat liver". Biochim. Biophys. Acta. 117 (1): 266–8. doi:10.1016/0304-4165(66)90177-2. PMID 5914340.
Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
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