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In the 1980s, he worked as an assistant editor on numerous films, commencing with All Summer in a Day (1982). His first editing credit was for Desperate Hours (1990), which was directed by Michael Cimino. Much of Rouse's work in the 1990s was in television. He edited the mini-series Anne Frank: The Whole Story (2002) for which he was nominated for an Emmy Award.
Rouse has worked on six films with director Paul Greengrass. The Bourne Supremacy (2004) was their first collaboration. Rouse had previously been an "additional editor" on the initial film in the Bourne series, The Bourne Identity (2002), that had been directed by Doug Liman. Frank Marshall, who co-produced the Bourne series, recommended Rouse to Greengrass.
The editing of their second feature together, United 93 (2006), received the BAFTA Award as well as nominations for the Academy Award and the ACE Eddie Award. Rouse won the Academy Award, the BAFTA Award, and the ACE Eddie for his third collaboration The Bourne Ultimatum (2007). He edited Greengrass' 2010 film Green Zone.
Several interviews of Rouse have been published where he discusses the editing of Greengrass's films. Greengrass is noted for a "cinéma vérité" style of filmmaking that uses several handheld cameras, and that creates opportunities for innovative editing. Ellen Feldman has written a detailed analysis of the editing of United 93. David Bordwell has discussed this aspect of the films as a further extension of "intensified continuity", which is a perspective on filmmaking that Bordwell has been developing for some years.
Wood, Jennifer M. (2007). "One Day in September"Archived 2008-02-06 at the Wayback Machine, interview with Christopher Rouse in Moviemaker, February 3, 2007; online version retrieved April 18, 2008.