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Cofrogliptin

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Chemical compound Pharmaceutical compound
Cofrogliptin
Clinical data
Other namesHSK7653
Legal status
Legal status
  • Investigational
Identifiers
IUPAC name
  • (2R,3S,5R,6S)-2-(2,5-Difluorophenyl)-5-(2-methylsulfonyl-4,6-dihydropyrrolopyrazol-5-yl)-6-(trifluoromethyl)oxan-3-amine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC18H19F5N4O3S
Molar mass466.43 g·mol

Cofrogliptin (developmental name HSK7653) is a long-acting DPP4 inhibitor dosed once every two weeks.

References

  1. Ji, Linong; Bian, Fang; Pan, Tianrong; Jiang, Hongwei; Jiang, Chengxia; Ren, Qian (20 June 2023). "55-OR: HSK7653, a Novel Ultralong-Acting DPP-4 Inhibitor, as Monotherapy in Patients With Type 2 Diabetes—A Randomized, Double-Blind, Placebo-Controlled Phase III Trial". Diabetes. 72 (Supplement_1). doi:10.2337/db23-55-OR. S2CID 259433641.
  2. Zhang, Miao; Zhang, Shudong; Yu, Zhiheng; Yao, Xueting; Lei, Zihan; Yan, Pangke; Wu, Nan; Wang, Xu; Hu, Qin; Liu, Dongyang (October 2023). "Dose decision of HSK7653 oral immediate release tablets in specific populations clinical trials based on mechanistic physiologically-based pharmacokinetic model". European Journal of Pharmaceutical Sciences. 189: 106553. doi:10.1016/j.ejps.2023.106553. PMC 10485820. PMID 37532063.
  3. Liu, Yang; Yan, Shuai; Liu, Jie; Liu, Hongzhong; Song, Ling; Yao, Xueting; Jiang, Ji; Li, Fangqiong; Du, Ke; Liu, Dongyang; Hu, Pei (May 2023). "Development and validation of an HPLC coupled with tandem mass spectrometry method for the determination of HSK7653, a novel super long‐acting dipeptidyl peptidase‐4 inhibitor, in human plasma and urine and its application to a pharmacokinetic study". Biomedical Chromatography. 37 (5). doi:10.1002/bmc.5607. PMID 36802077. S2CID 257048524.
  4. Bai, Nan; Wang, Jin; Liang, Wenxin; Gao, Leili; Cui, Wei; Wu, Qinghe; Li, Fangqiong; Ji, Linong; Cai, Yun (6 November 2023). "A Multicenter, Randomized, Double-Blind, Placebo-Controlled, and Dose-Increasing Study on the Safety, Tolerability and PK/PD of Multiple Doses of HSK7653 by Oral Administration in Patients with Type 2 Diabetes Mellitus in China". Diabetes Therapy. doi:10.1007/s13300-023-01496-0. PMC 10786778. PMID 37930584.
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