Cole-Hamilton is a British surname. It can refer to:
- Arthur Cole-Hamilton (1750–1810), Anglo-Irish politician
- Alex Cole-Hamilton (born 1977), Scottish politician
- Anni Cole-Hamilton, founder of Moray Firth School
- Air Vice Marshal John Cole-Hamilton (1894–1945), British military commander
- Josh Hamilton (actor) (born 1969), American actor, born Joshua Cole Hamilton
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