Comalapa is a compound Nahuatl word derived from comalli ("griddle")+"apa" ("place of"), it may refer to any of the following geographical locations:
- El Salvador
- Comalapa, Chalatenango, El Salvador
- Comalapa, La Paz, location of the Comalapa International Airport, in La Paz Department
- Comalapa River, river in the La Paz Department of El Salvador
- Guatemala
- San Juan Comalapa, Chimaltenango
- Mexico
- Nicaragua
- Comalapa, Chontales, Departamento de Chontales
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