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Ibuprofen/paracetamol, sold under the brand name Combogesic among others, is a fixed-dose combination of two medications, ibuprofen, a non-steroidal anti-inflammatory drug (NSAID); and paracetamol (acetaminophen), an analgesic and antipyretic. It is available as a generic medication.

Medical uses

Ibuprofen/paracetamol is indicated for the short term management of mild to moderate acute pain.

There is evidence that paracetamol combined with ibuprofen provides pain relief better than either medication used alone.

Adverse effects

Society and culture

Brand names

The combination is available as Combiflam, Advil Dual Action with Acetaminophen, Ibupane, Nuromol and Combogesic.

References

1. ^ "Ibupane" (PDF). TGA eBS. Archived from the original on 29 October 2020. Retrieved 29 April 2023.
2. "Nuromol Dual Action Pain Relief 200mg/500mg tablets - Summary of Product Characteristics (SmPC)". (emc). 15 June 2022. Archived from the original on 25 February 2023. Retrieved 24 February 2023.
3. "Nuromol Pain Relief 200mg/500mg Film Coated Tablets - Summary of Product Characteristics (SmPC)". (emc). 15 June 2022. Archived from the original on 25 February 2023. Retrieved 24 February 2023.
4. "Nuromol public assessment report". GOV.UK. 16 August 2021. Archived from the original on 25 February 2023. Retrieved 24 February 2023.
5. "Nuromol Dual Action Pain Relief 200mg/500mg tablets (ibuprofen/paracetamol): public consultation". GOV.UK. 13 May 2021. Archived from the original on 25 February 2023. Retrieved 24 February 2023.
6. ^ "Advil Dual Action with Acetaminophen- ibuprofen, acetaminophen tablet, film coated". DailyMed. 1 December 2021. Archived from the original on 25 February 2023. Retrieved 25 February 2023.
7. ^ "Combogesic- acetaminophen and ibuprofen tablet, film coated". DailyMed. 9 March 2023. Archived from the original on 7 July 2024. Retrieved 6 July 2024.
8. "Combogesic IV- acetaminophen and ibuprofen injection injection". DailyMed. 29 April 2024. Archived from the original on 7 July 2024. Retrieved 6 July 2024.
9. "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.
10. "First Generic Drug Approvals 2023". U.S. Food and Drug Administration (FDA). 30 May 2023. Archived from the original on 30 June 2023. Retrieved 30 June 2023.
11. ^ "Combiflam". drugs.com. Archived from the original on 5 February 2015. Retrieved 5 February 2015.
12. Ong CK, Seymour RA, Lirk P, Merry AF (April 2010). "Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain". Anesthesia and Analgesia. 110 (4): 1170–9. doi:10.1213/ANE.0b013e3181cf9281. PMID 20142348. S2CID 7948680.
13. Moore RA, Derry C (January 2013). "Efficacy of OTC analgesics". International Journal of Clinical Practice. Supplement. 67 (178): 21–5. doi:10.1111/ijcp.12054. PMID 23163544. S2CID 205184492.
14. "Combiflam". Sanofi India. 28 February 2023. Archived from the original on 3 March 2023. Retrieved 2 March 2023.
15. "Advil Dual Action: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 26 September 2020. Retrieved 28 February 2020.
16. "Drug Approval Package: Advil Dual Action with Acetaminophen". U.S. Food and Drug Administration (FDA). 31 March 2020. Archived from the original on 3 March 2023. Retrieved 2 March 2023.
17. "FDA approves GSK's Advil Dual Action with Acetaminophen for over-the-counter use in the United States" (Press release). GSK Consumer Healthcare. 28 February 2020. Archived from the original on 29 February 2020. Retrieved 28 February 2020 – via PR Newswire.

• Medicine

• Analgesics
• Anti-inflammatory and antirheumatic products
• Antipyretics
• Combination analgesics
• Drugs developed by Pfizer
• Drugs developed by GSK plc