Commisso is an Italian surname. Notable people with the surname include:
- Antonio Commisso (born 1956), Italian mobster of the Commisso 'ndrina
- Cosimo Commisso (criminal) (born 1950), Italian mobster of the Commisso 'ndrina
- Cosimo Commisso (scientist), Canadian biologist
- Cosimo Commisso (soccer), Canadian soccer player
- Emilio Commisso (born 1956), Argentine footballer
- Eduardo Commisso (born 1948), Argentine footballer
- Rocco B. Commisso (born 1949), Italian-American businessman, chairman of Mediacom Communications
See also
- Commisso's Food Markets, former Canadian supermarket chain
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