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C8 complex

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(Redirected from Complement component 8A) Protein involved in the complement system
High Resolution Crystal Structure of Human Complement Component 8

Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC).

A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.

Membrane attack complex. Some labels are in Polish.
complement component 8, alpha polypeptide
Identifiers
SymbolC8A
NCBI gene731
HGNC1352
OMIM120950
RefSeqNM_000562
UniProtP07357
Other data
LocusChr. 1 p36.2-22.1
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StructuresSwiss-model
DomainsInterPro
complement component 8, beta polypeptide
Identifiers
SymbolC8B
NCBI gene732
HGNC1353
OMIM1209660
RefSeqNM_000066
UniProtP073o58
Other data
LocusChr. 1 p36.2-22.1
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StructuresSwiss-model
DomainsInterPro
complement component 8, gamma polypeptide
Identifiers
SymbolC8G
NCBI gene733
HGNC1354
OMIM120930
RefSeqNM_000606
UniProtP07360
Other data
LocusChr. 9 q34.3
Search for
StructuresSwiss-model
DomainsInterPro

Structure

C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the genes C8A, C8B and C8G respectively.

References

  1. PDB: 3OJY​; Lovelace LL, Cooper CL, Sodetz JM, Lebioda L (May 2011). "Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement". The Journal of Biological Chemistry. 286 (20): 17585–92. doi:10.1074/jbc.M111.219766. PMC 3093833. PMID 21454577.

External links

Complement system
Pathways
Activators/enzymes
Early
Middle
Late
Inhibitors
Complement receptors
Function


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