| Corticotropin-releasing hormone binding protein (CRH-BP) | |||||||||
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| Identifiers | |||||||||
| Symbol | CRH-BP | ||||||||
| Pfam | PF05428 | ||||||||
| InterPro | IPR008435 | ||||||||
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Corticotropin-releasing hormone binding protein (CRH-BP) binds corticotropin-releasing hormone (CRH) and several related peptide hormones (urocortin 1, urotensin 1, and sauvagine). It is an ancient, highly conserved protein whose origin predates the divergence of protostomes and deuterostomes.
Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. It is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development.
Corticotropin-releasing factor binding protein (CRH-BP) is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors 1 and 2. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development.
Human proteins
References
- Ketchesin, Kyle D.; Stinnett, Gwen S.; Seasholtz, Audrey F. (2017-09-03). "Corticotropin-releasing hormone-binding protein and stress: from invertebrates to humans". Stress. 20 (5): 449–464. doi:10.1080/10253890.2017.1322575. ISSN 1025-3890. PMC 7885796. PMID 28436309. S2CID 41347737.
- ^ Huising, Mark O.; Flik, Gert (May 2005). "The Remarkable Conservation of Corticotropin-Releasing Hormone (CRH)-Binding Protein in the Honeybee ( Apis mellifera ) Dates the CRH System to a Common Ancestor of Insects and Vertebrates". Endocrinology. 146 (5): 2165–2170. doi:10.1210/en.2004-1514. hdl:2066/33202. ISSN 0013-7227. PMID 15718273.
- De Groef, Bert; Van der Geyten, Serge; Darras, Veerle M.; Kühn, Eduard R. (March 2006). "Role of corticotropin-releasing hormone as a thyrotropin-releasing factor in non-mammalian vertebrates". General and Comparative Endocrinology. 146 (1): 62–68. doi:10.1016/j.ygcen.2005.10.014. PMID 16337947.
- Seasholtz AF, Valverde RA, Denver RJ (2002). "Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals". J. Endocrinol. 175 (1): 89–97. doi:10.1677/joe.0.1750089. PMID 12379493.