| Costunolide synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.120 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Costunolide synthase (EC 1.14.13.120) is an enzyme with systematic name germacra-1(10),4,11(13)-trien-12-oate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating). This enzyme catalyses the following chemical reaction
- germacra-1(10),4,11(13)-trien-12-oate + NADPH + H + O2 (+)-costunolide + NADP + 2 H2O
(+)-costunolide + NADP + 2 H2OCostunolide synthase is a heme-thiolate protein (P-450).
References
- de Kraker JW, Franssen MC, Joerink M, de Groot A, Bouwmeester HJ (May 2002). "Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome p450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory". Plant Physiology. 129 (1): 257–68. doi:10.1104/pp.010957. PMC 155889. PMID 12011356.
External links
- Costunolide+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
| Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14) | |
|---|---|
| 1.14.11: 2-oxoglutarate | |
| 1.14.13: NADH or NADPH | |
| 1.14.14: reduced flavin or flavoprotein | |
| 1.14.15: reduced iron–sulfur protein | |
| 1.14.16: reduced pteridine (BH4 dependent) | |
| 1.14.17: reduced ascorbate | |
| 1.14.18-19: other | |
| 1.14.99 - miscellaneous | |
| Enzymes | |
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| Activity | |
| Regulation | |
| Classification | |
| Kinetics | |
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