Crippler or Cripplers may refer to:
- Any disease such as Poliomyelitis with a disabling effect
- cripplers, small bore guns excluded from grouse shooting
- Horse Crippler cactus, Echinocactus texensis
- Crippler (comics), a fictional character in Marvel Comics
- The Crippler, nickname of professional wrestler Chris Benoit
- The Crippler, nickname of professional wrestler Ray Stevens
- The Crippler, nickname of mixed martial artist Chris Leben
- Cripplers (EP), by the hardcore punk band This Is Hell.
- Cripplers, a possible etymology of the Crips street gang
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