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Cu2+-exporting ATPase

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Cu-exporting ATPase
Identifiers
EC no.3.6.3.4
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Cu-exporting ATPase (EC 3.6.3.4) is an enzyme with systematic name ATP phosphohydrolase (Cu-exporting). This enzyme catalyses the following chemical reaction

ATP + H2O + Cuin {\displaystyle \rightleftharpoons } ADP + phosphate + Cuout

This P-type ATPase undergoes covalent phosphorylation during the transport cycle.

See also

References

  1. Vulpe C, Levinson B, Whitney S, Packman S, Gitschier J (January 1993). "Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase". Nature Genetics. 3 (1): 7–13. doi:10.1038/ng0193-7. PMID 8490659.
  2. Petrukhin K, Lutsenko S, Chernov I, Ross BM, Kaplan JH, Gilliam TC (September 1994). "Characterization of the Wilson disease gene encoding a P-type copper transporting ATPase: genomic organization, alternative splicing, and structure/function predictions". Human Molecular Genetics. 3 (9): 1647–56. doi:10.1093/hmg/3.9.1647. PMID 7833924.
  3. Fagan MJ, Saier MH (January 1994). "P-type ATPases of eukaryotes and bacteria: sequence analyses and construction of phylogenetic trees". Journal of Molecular Evolution. 38 (1): 57–99. doi:10.1007/bf00175496. PMID 8151716.

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Hydrolases: acid anhydride hydrolases (EC 3.6)
3.6.1
3.6.2
3.6.3-4: ATPase
3.6.3
Cu++ (3.6.3.4)
Ca+ (3.6.3.8)
Na+/K+ (3.6.3.9)
H+/K+ (3.6.3.10)
Other P-type ATPase
3.6.4
3.6.5: GTPase
3.6.5.1: Heterotrimeric G protein
3.6.5.2: Small GTPase > Ras superfamily
3.6.5.3: Protein-synthesizing GTPase
3.6.5.5-6: Polymerization motors
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