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Cystoscopy
Diagram showing a cystoscopy for a male and a female
Pronunciation	sis-ˈtäs-kə-pē
ICD-9-CM	57.31-57.33
MeSH	D003558
MedlinePlus	003903
[edit on Wikidata]

Cystoscopy is endoscopy of the urinary bladder via the urethra. It is carried out with a cystoscope.

The urethra is the tube that carries urine from the bladder to the outside of the body. The cystoscope has lenses like a telescope or microscope. These lenses let the physician focus on the inner surfaces of the urinary tract. Some cystoscopes use optical fibres (flexible glass fibres) that carry an image from the tip of the instrument to a viewing piece at the other end. Cystoscopes range from pediatric to adult and from the thickness of a pencil up to approximately 9 mm and have a light at the tip. Many cystoscopes have extra tubes to guide other instruments for surgical procedures to treat urinary problems.

There are two main types of cystoscopy—flexible and rigid—differing in the flexibility of the cystoscope. Flexible cystoscopy is carried out with local anaesthesia on both sexes. Typically, a topical anesthetic, most often xylocaine gel (common brand names are Anestacon and Instillagel) is employed. The medication is instilled into the urethra via the urinary meatus five to ten minutes prior to the beginning of the procedure. Rigid cystoscopy can be performed under the same conditions, but is generally carried out under general anesthesia, particularly in male subjects, due to the pain caused by the probe. The sizes of the sheath of the rigid cystoscope are 17 French gauge (5.7 mm diameter), 19 Fr gauge (6.3 mm diameter), and 22 Fr gauge (7.3 mm diameter).

Medical uses

Cystoscopy may be recommended for any of the following conditions:

• urinary tract infections;
• blood in the urine (hematuria);
• loss of bladder control (incontinence) or overactive bladder; (Although, the American Urogynecologic Society does not recommend that cystoscopy, urodynamics, or diagnostic renal and bladder ultrasound are part of initial diagnosis for uncomplicated overactive bladder.)
• unusual cells found in urine sample;
• need for a bladder catheter;
• painful urination, chronic pelvic pain, or interstitial cystitis;
• urinary blockage such as from prostate enlargement, stricture, or narrowing of the urinary tract;
• stone in the urinary tract; and
• unusual growth, polyp, tumor, or cancer.

Male and female urinary tracts

If a patient has a stone lodged higher in the urinary tract, the physician may use a much finer calibre scope called a ureteroscope through the bladder and up into the ureter. (The ureter is the tube that carries urine from the kidney to the bladder.) The physician can then see the stone and remove it with a small basket at the end of a wire that is inserted through an extra tube in the ureteroscope. For larger stones, the physician may also use the extra tube in the ureteroscope to extend a flexible fiber that carries a laser beam to break the stone into smaller pieces that can then pass out of the body in the urine.

Test procedures

Physicians may have special instructions, but in most cases, patients are able to eat normally and return to normal activities after the test. Patients are sometimes asked to give a urine sample before the test to check for infection. These patients should ensure that they do not urinate for a sufficient period of time, such that they are able to urinate prior to this part of the test.

Patients will have to remove their clothing covering the lower part of the body, although some physicians may prefer if the patient wears a hospital gown for the examination and covers the lower part of the body with a sterile drape. In most cases, patients lie on their backs with their knees slightly parted. Occasionally, a patient may also need to have his or her knees raised. This is particularly true when undergoing a Rigid Cystoscopy examination. For flexible cystoscopy procedures the patient is almost always alert and a local anesthetic is applied to reduce discomfort. In cases requiring a rigid cystoscopy it is not unusual for the patient to be given a general anesthetic, as these can be more uncomfortable, particularly for men. A physician, nurse, or technician will clean the area around the urethral opening and apply a local anesthetic. The local anesthetic is applied direct from a tube or needleless syringe into the urinary tract. Often, skin preparation is performed with chlorhexidine.

Patients receiving a ureteroscopy may receive a spinal or general anaesthetic.

The physician will gently insert the tip of the cystoscope into the urethra and slowly glide it up into the bladder. The procedure is more painful for men than for women due to the length and narrow diameter of the male urethra, and results of a 2019 systematic review of the literature found that intraurethral lidocaine greatly reduces this painful procedure in men. Relaxing the pelvic muscles helps make this part of the test easier. A sterile liquid (water, saline, or glycine solution) will flow through the cystoscope to slowly fill the bladder and stretch it so that the physician has a better view of the bladder wall.

As the bladder reaches capacity, patients typically feel some mild discomfort and the urge to urinate.

The time from insertion of the cystoscope to removal may be only a few minutes, or it may be longer if the physician finds a stone and decides to remove it, or in cases where a biopsy is required. Taking a biopsy (a small tissue sample for examination under a microscope) will also make the procedure last longer. In most cases, the entire examination, including preparation, will take about 15 to 20 minutes.

Blue light

In blue light cystoscopy hexyl aminolevulinate hydrochloride is instilling a photosensitizing agent, into the bladder. The blue light cystoscopy contains a light source and light is transmitted through a fluid light cable connected to an endoscope to light up the area to be observed. The photosensitizing agent preferentially accumulates porphyrins in malignant cells as opposed to nonmalignant cells of urothelial origin. Under subsequent blue light illumination, neoplastic lesions fluoresce red, enabling visualization of tumors. The blue light cystoscopy is used to detect non-muscle invasive papillary cancer of the bladder.

Indications before and after the procedure

Before the procedure

Prior to the early 1990s, it was common practice for the physician performing the procedure to prescribe an antibiotic to take for a few days to prevent an infection. Since that time, many urologists will order a "urine C & S" (urinalysis with bacterial/fungal cultures and testing for sensitivities to anti-infective medications) prior to the performance of the cystoscopy, and as part of the pre-operative workup. Depending on the results of the testing and other circumstances, he or she may elect to prescribe a 10- to 14-day course of antibiotic or other anti-infective treatment, commencing 3 days before the cystoscopy is to be performed, as this may alleviate some inflammation of the urethra prior to the procedure.

This practice may provide an additional benefit by preventing an accidental infection from occurring during the procedure. When antibiotics are given for UTI prevention in adults undergoing a cystoscopy, they may reduce the risk of infections that go into the bloodstream and infections limited to the bladder. However, antibiotics may have little to no effect on only the risk of serious infections that go in the bloodstream. From review data, antibiotics do not appear to cause serious unwanted side effects or affect the occurrence of minor side effects, but more research is needed to confirm these findings. The full-course of antibiotic treatment also lessens the possibility of the bacteria becoming resistant to the antibiotic/anti-infective agent prescribed.

Physicians may also prescribe an oral urinary analgesic, phenazopyridine, or a combination (urinary) analgesic/anti-infective/anti-spasmodic medication containing methylene blue, methanamine, hyoscyamine sulfate and phenyl salicylate for irritation and/or dysuria patients may experience after the procedure. At two weeks post-procedure, the practitioner may order a follow-up evaluation including a repeat of the urinalysis with cultures and sensitivities, and a uroflowmetric study (which evaluates the volume of urine released from the body, the speed with which it is released, and how long the release takes)

After the procedure

Patients often experience a burning sensation during urination and often see small amounts of blood in their urine. Procedures using rigid instrumentation more frequently result in short-term urinary incontinence and leakage due to urethral damage. Occasionally, patients may feel some lower abdominal pains, reflecting bladder muscle spasms, but these are not common.

Common (non-invasive) prescriptions to relieve discomfort after the test may include:

• drinking 32 fluid ounces (1 L) of water over 2 hours;
• taking a warm bath to relieve the burning feeling; and
• holding a warm, damp washcloth over the urethral opening.

Other animals

Cystoscopy has similar indications in animals, including visualisation and biopsy of mucosa, retrieval or destruction of urinary bladder stones and diagnosis of ectopic ureters.

In turtle and tortoises, cystoscopy has additional value as it permits the visualisation of internal organs due to the thin urinary bladder wall. In young individuals in which sex determination would not be feasible by visualisation of external morphologic features, this technique permits noninvasive visualisation of gonads, and therefore sex determination.

References

1. "Cystoscopy and Ureteroscopy". The Doctors Lounge. Archived from the original on 2011-07-10. Retrieved 2008-01-29.
2. American Urogynecologic Society (May 5, 2015). "Five Things Physicians and Patients Should Question". Choosing Wisely: an initiative of the ABIM Foundation. American Urogynecologic Society. Retrieved June 1, 2015.
3. Gormley EA, Lightner DJ, Faraday M, Vasavada SP (May 2015). "Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline amendment". The Journal of Urology. 193 (5): 1572–80. doi:10.1016/j.juro.2015.01.087. PMID 25623739.
4. "Pharmaceutical Information – Hibitane". RxMed. Archived from the original on 2014-02-03. Retrieved 2013-06-09.
5. Raskolnikov D, Brown B, Holt SK, Ball AL, Lotan Y, Strope S, Schroeck F, Ullman R, Lipman R, Smith AB, Gore JL (2019). "Reduction of Pain during Flexible Cystoscopy: A Systematic Review and Meta-Analysis". Journal of Urology. 202 (6): 1136–1142. doi:10.1097/JU.0000000000000399. ISSN 0022-5347. PMID 31219763. S2CID 195192577.
6. "Photodynamic Diagnostic D-Light C (PDD) System – P050027". FDA. Archived from the original on 18 January 2017.
7. Mark JR, Gelpi-Hammerschmidt F, Trabulsi EJ, Gomella LG (April 2012). "Blue light cystoscopy for detection and treatment of non-muscle invasive bladder cancer" (PDF). The Canadian Journal of Urology. 19 (2): 6227–31. PMID 22512972.
8. ^ Zeng S, Zhang Z, Bai Y, Sun Y, Xu C, et al. (Cochrane Urology Group) (February 2019). "Antimicrobial agents for preventing urinary tract infections in adults undergoing cystoscopy". The Cochrane Database of Systematic Reviews. 2019 (2): CD012305. doi:10.1002/14651858.CD012305.pub2. PMC 6383548. PMID 30789676.
9. Morgan M, Forman M (July 2015). "Cystoscopy in dogs and cats". review. The Veterinary Clinics of North America. Small Animal Practice. 45 (4): 665–701. doi:10.1016/j.cvsm.2015.02.010. PMID 26002795.
10. Childress MO, Adams LG, Ramos-Vara JA, Freeman LJ, He S, Constable PD, Knapp DW (August 2011). "Results of biopsy via transurethral cystoscopy and cystotomy for diagnosis of transitional cell carcinoma of the urinary bladder and urethra in dogs: 92 cases (2003-2008)". Journal of the American Veterinary Medical Association. 239 (3): 350–6. doi:10.2460/javma.239.3.350. PMID 21801049.
11. Smith AL, Radlinsky MG, Rawlings CA (July 2010). "Cystoscopic diagnosis and treatment of ectopic ureters in female dogs: 16 cases (2005-2008)". Journal of the American Veterinary Medical Association. 237 (2): 191–5. doi:10.2460/javma.237.2.191. PMID 20632793.
12. Di Girolamo N, Selleri P (September 2015). "Clinical Applications of Cystoscopy in Chelonians". The Veterinary Clinics of North America. Exotic Animal Practice. 18 (3): 507–26. doi:10.1016/j.cvex.2015.04.008. PMID 26336001.
13. Selleri P, Di Girolamo N, Melidone R (June 2013). "Cystoscopic sex identification of posthatchling chelonians". Journal of the American Veterinary Medical Association. 242 (12): 1744–50. doi:10.2460/javma.242.12.1744. PMID 23725439.

• An earlier version of this article was adapted from the public domain NIH Publication No. 01-4800, which says, "This e-text is not copyrighted. The clearinghouse encourages users of this e-pub to duplicate and distribute as many copies as desired."

Further reading

• Cystoscopy and Ureteroscopy on the National Institute of Diabetes and Digestive and Kidney Diseases website

• Endoscopy
• Urologic procedures